Ultrashort plasma cell-free DNA: a novel non-invasive marker for cancer diagnostics.

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2024-08-25 eCollection Date: 2024-01-01 DOI:10.62347/UQTM2281
Guodong Zhao
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Abstract

Recent studies have shown that ultrashort plasma cell-free DNA (uscfDNA), a novel type of cfDNA fragment approximately 50 nucleotides long, differs from conventional monocyte-derived cfDNA in several aspects, including specific extraction requirements and a higher incidence of tumor-specific genetic alterations. uscfDNA shows promise in enhancing liquid biopsy sensitivity for cancer detection, with distinct methylation profiles observed in cancer patients. These findings suggest uscfDNA analysis could significantly improve non-invasive cancer diagnostics, offering new avenues for early detection and personalized medicine strategies.

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超短等离子体无细胞 DNA:癌症诊断的新型无创标记物。
最近的研究表明,超短无血浆细胞DNA(uscfDNA)是一种新型的cfDNA片段,长约50个核苷酸,它与传统的单核细胞衍生cfDNA有多方面的不同,包括特定的提取要求和更高的肿瘤特异性基因改变发生率。这些研究结果表明,uscfDNA 分析可显著改善非侵入性癌症诊断,为早期检测和个性化医疗策略提供新途径。
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