Ultrashort plasma cell-free DNA: a novel non-invasive marker for cancer diagnostics.

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2024-08-25 eCollection Date: 2024-01-01 DOI:10.62347/UQTM2281
Guodong Zhao
{"title":"Ultrashort plasma cell-free DNA: a novel non-invasive marker for cancer diagnostics.","authors":"Guodong Zhao","doi":"10.62347/UQTM2281","DOIUrl":null,"url":null,"abstract":"<p><p>Recent studies have shown that ultrashort plasma cell-free DNA (uscfDNA), a novel type of cfDNA fragment approximately 50 nucleotides long, differs from conventional monocyte-derived cfDNA in several aspects, including specific extraction requirements and a higher incidence of tumor-specific genetic alterations. uscfDNA shows promise in enhancing liquid biopsy sensitivity for cancer detection, with distinct methylation profiles observed in cancer patients. These findings suggest uscfDNA analysis could significantly improve non-invasive cancer diagnostics, offering new avenues for early detection and personalized medicine strategies.</p>","PeriodicalId":72163,"journal":{"name":"American journal of clinical and experimental immunology","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411157/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of clinical and experimental immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.62347/UQTM2281","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Recent studies have shown that ultrashort plasma cell-free DNA (uscfDNA), a novel type of cfDNA fragment approximately 50 nucleotides long, differs from conventional monocyte-derived cfDNA in several aspects, including specific extraction requirements and a higher incidence of tumor-specific genetic alterations. uscfDNA shows promise in enhancing liquid biopsy sensitivity for cancer detection, with distinct methylation profiles observed in cancer patients. These findings suggest uscfDNA analysis could significantly improve non-invasive cancer diagnostics, offering new avenues for early detection and personalized medicine strategies.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
超短等离子体无细胞 DNA:癌症诊断的新型无创标记物。
最近的研究表明,超短无血浆细胞DNA(uscfDNA)是一种新型的cfDNA片段,长约50个核苷酸,它与传统的单核细胞衍生cfDNA有多方面的不同,包括特定的提取要求和更高的肿瘤特异性基因改变发生率。这些研究结果表明,uscfDNA 分析可显著改善非侵入性癌症诊断,为早期检测和个性化医疗策略提供新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Advance in the mechanism and clinical research of myalgia in long COVID. Characterization of tumor suppressors and oncogenes evaluated from TCGA cancers. Clinical utility of multi-row spiral CT in diagnosing hepatic nodular lesions, gastric cancer, and Crohn's disease: a comprehensive meta-analysis. Effectiveness study of surface electromyography combined with spine 3D data system to evaluate scoliosis. The relationship between metabolites and gout: a Mendelian randomization study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1