A Captivating Potential of Schiff Bases Derivatives for Antidiabetic Activity.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY Current pharmaceutical design Pub Date : 2024-09-20 DOI:10.2174/0113816128339161240913055034

Rakesh Sahu, Kamal Shah

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Abstract

A double bond between the nitrogen and carbon atoms characterizes a wide class of compounds known as Schiff bases. The flexibility of Schiff bases is formed from several methods and may be combined with alkyl or aryl substituents. The group is a part of organic compounds, either synthetic or natural, and it serves as a precursor and an intermediate in drugs that have therapeutic action. The review focuses on molecular docking and structure-activity relationship (SAR) analysisfor antidiabetic effects of the different non-metal Schiff bases. Many studies have found that Schiff bases are used as linkers in an extensive range of synthesized compounds and other activities. Thus, this current study aims to give the scientific community a thoughtful look at the principal ideas put forward by investigators regarding antidiabetic actions exhibited by certain Schiff-based derivatives, as this review covered many aspects, including docking and SAR analysis. For individuals who intend to create novel antidiabetic compounds with Schiff bases as pharmacophores or physiologically active moieties, it will be an invaluable informational resource.

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希夫碱衍生物抗糖尿病的迷人潜力

氮原子和碳原子之间的双键是希夫碱一类化合物的特征。希夫碱的柔韧性由多种方法形成，可与烷基或芳基取代基结合。该基团是合成或天然有机化合物的一部分，也是具有治疗作用的药物的前体和中间体。这篇综述重点分析了不同非金属席夫碱的分子对接和结构-活性关系（SAR）分析，以了解它们的抗糖尿病作用。许多研究发现，希夫碱在大量合成化合物和其他活动中被用作连接剂。因此，本研究旨在让科学界深入了解研究人员就某些席夫碱衍生物的抗糖尿病作用提出的主要观点，因为本综述涵盖了许多方面，包括对接和 SAR 分析。对于打算用希夫碱作为药源或生理活性分子来开发新型抗糖尿病化合物的人来说，这将是一个宝贵的信息资源。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.