Early maturation of neural auditory novelty detection − Typical development with no major effects of dyslexia risk or music intervention

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-09-14 DOI:10.1016/j.clinph.2024.09.005

T. Kujala , V. Putkinen , P. Virtala

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Abstract

Objective

To determine the early development of novelty detection and the effect of familial dyslexia risk and infant music intervention on this development.

Methods

In the longitudinal DyslexiaBaby study, we investigated the maturation of novelty-P3 and late-discriminative negativity (LDN) event-related potentials to novel sounds at birth (N = 177) and at the ages of 6 (N = 83) and 28 months (N = 131).

Results

Novelty-P3 was elicited at all ages, whereas LDN was elicited at 6 and 28 months. Novelty-P3 amplitude was largest at 6 months, and its latency decreased with age. LDN amplitude decreased and latency increased between 6 to 28 months. Dyslexia risk or intervention had no effects, apart from a longer LDN latency in the high-risk than no-risk group.

Conclusions

Already neonates respond to novel environmental sounds, indicating prerequisites for detecting potentially relevant events at birth. Maturation influences neural novelty detection.

Significance

Novelty detection is crucial for perceiving important events, but its early development has been scarcely studied. We found, with a large sample, that neonates detect novel events, and showed the developmental pattern of its neural signature. The results serve as a reference for studies on typical and atypical novelty-detection development in infancy when behavioral testing is challenging.

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神经听觉新奇感检测的早期成熟--典型的发展，没有阅读障碍风险或音乐干预的重大影响

方法在 "阅读障碍婴儿 "纵向研究中，我们调查了婴儿出生时（177 人）、6 个月时（83 人）和 28 个月时（131 人）对新奇声音的新奇-P3 和晚期鉴别性否定（LDN）事件相关电位的成熟情况。新奇-P3 振幅在 6 个月时最大，其潜伏期随年龄增长而缩短。在 6 到 28 个月期间，LDN 振幅减小，潜伏期增加。除了高风险组的LDN潜伏期长于无风险组之外，阅读障碍风险或干预没有影响。意义新颖性检测对感知重要事件至关重要，但对其早期发展的研究却很少。我们在一个大样本中发现，新生儿能检测到新奇事件，并显示了其神经特征的发育模式。在行为测试具有挑战性的情况下，这些结果可作为婴儿期典型和非典型新奇事物检测发展研究的参考。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.