Crossover evaluation of time-of-flight-based attenuation correction in brain ¹⁸F-FDG and ¹⁸F-flutemetamol PET.

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Annals of Nuclear Medicine Pub Date : 2024-09-30 DOI:10.1007/s12149-024-01986-6

Takahiro Yamada, Kohei Hanaoka, Daisuke Morimoto-Ishikawa, Yoshiyuki Yamakawa, Shiho Kumakawa, Atsushi Ohtani, Tetsuro Mizuta, Hayato Kaida, Kazunari Ishii

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Abstract

Background: Brain-dedicated positron emission tomography (PET) systems offer high spatial resolution and sensitivity for accurate clinical assessments. Attenuation correction (AC) is important in PET imaging, particularly in brain studies. This study assessed the reproducibility of attenuation maps (µ-maps) generated by a specialized time-of-flight (TOF) brain-dedicated PET system for imaging using different PET tracers.

Methods: Twelve subjects underwent both ¹⁸F-fluorodeoxyglucose (FDG)-PET and ¹⁸F-flutemetamol (FMM) amyloid-PET scans. Images were reconstructed with µ-maps obtained by a maximum likelihood-based AC method. Voxel-based and region-based analyses were used to compare µ-maps obtained with FDG-PET versus FMM-PET; FDG-PET images reconstructed using an FDG-PET µ-map (FDG × FDG) versus those reconstructed with an FMM-PET µ-map (FDG × FMM); and FMM-PET images reconstructed using an FDG-PET µ-map (FMM × FDG) versus those reconstructed with an FMM-PET µ-map (FMM × FMM).

Results: Small but significant differences in µ-maps were observed between tracers, primarily in bone regions. In the comparison between the µ-maps obtained with FDG-PET and FMM-PET, the µ-maps obtained with FDG-PET had higher µ-values than those obtained with FMM-PET in the parietal regions of the head and skull, in a portion of the cerebellar dentate nucleus and on the surface of the frontal lobe. The comparison between FDG and FDG × FMM values in different regions yielded findings similar to those of the µ-maps comparison. FDG × FMM values were significantly higher than FDG values in the bilateral temporal bones and a small part of the temporal lobe. Similarly, FMM values were significantly higher than FMM × FDG values in the bilateral temporal bones. FMM × FDG values were significantly higher than FMM values in a small area of the right cerebellar hemisphere. However, the relative errors in these µ-maps were within ± 4%, suggesting that they are clinically insignificant. In PET images reconstructed with the original and swapped µ-maps, the relative errors were within ± 7% and the quality was nearly equivalent.

Conclusion: These findings suggest the clinical reliability of the AC method without an external radiation source in TOF brain-dedicated PET systems.

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在脑 18F-FDG 和 18F-flutemetamol PET 中交叉评估基于飞行时间的衰减校正。

背景：脑专用正电子发射断层扫描（PET）系统具有高空间分辨率和灵敏度，可用于准确的临床评估。衰减校正（AC）在 PET 成像中非常重要，尤其是在脑部研究中。本研究评估了专门的飞行时间（TOF）脑专用 PET 系统在使用不同 PET 示踪剂进行成像时生成的衰减图（µ-map）的可重复性：12名受试者同时接受了18F-氟脱氧葡萄糖（FDG）-PET和18F-氟替美托咪醇（FMM）淀粉样蛋白-PET扫描。通过基于最大似然 AC 方法获得的 µ 地图对图像进行了重建。使用基于体素和基于区域的分析方法比较了 FDG-PET 与 FMM-PET 获得的 µ 地图；使用 FDG-PET µ 地图 (FDG × FDG) 重建的 FDG-PET 图像与使用 FMM-PET µ 地图 (FDG × FMM) 重建的 FDG-PET 图像；以及使用 FDG-PET µ 地图 (FMM × FDG) 重建的 FMM-PET 图像与使用 FMM-PET µ 地图 (FMM × FMM) 重建的 FMM-PET 图像：结果：不同示踪剂的µ映射存在微小但明显的差异，主要是在骨骼区域。在对使用 FDG-PET 和 FMM-PET 获得的µ图进行比较时，在头部和头骨顶区、小脑齿状核的一部分以及额叶表面，使用 FDG-PET 获得的µ图的µ值高于使用 FMM-PET 获得的µ图。不同区域的 FDG 值和 FDG × FMM 值的比较结果与 µ 图谱比较结果相似。在双侧颞骨和颞叶的一小部分，FDG × FMM 值明显高于 FDG 值。同样，在双侧颞骨，FMM 值明显高于 FMM × FDG 值。在右侧小脑半球的一小部分区域，FMM × FDG 值明显高于 FMM 值。不过，这些 µ 地图的相对误差在 ± 4% 以内，表明它们在临床上并不重要。在使用原始和交换 µ 地图重建的 PET 图像中，相对误差在 ± 7% 以内，质量几乎相当：这些研究结果表明，在 TOF 脑专用 PET 系统中，无需外部辐射源的 AC 方法具有临床可靠性。

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来源期刊

Annals of Nuclear Medicine 医学-核医学

CiteScore

4.90

自引率

7.70%

发文量

111

审稿时长

4-8 weeks

期刊介绍： Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.