Efficacy of 1060 nm Diode Laser for Non-Invasive Subcutaneous Fat Reduction in Mini-Pigs.

IF 1.9 4区医学 Q3 DERMATOLOGY Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-09-20 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S471367

Yea-Jin Lee, Namgue Hong, Eun Seo Choi, Sun-Hyang Choi, Eun Young Kim, Hyeong Ju Park, Jin-Chul Ahn

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Abstract

Purpose: To evaluate the efficacy and safety of abdominal fat reduction in mini-pigs, utilizing at 1060 nm diode laser with a wavelength of 1060 nm.

Patients and methods: The laser system non-invasively disrupts adipose tissue; its effectiveness and safety were evaluated by ultrasound imaging and histological analysis. Laser irradiation was performed with various powers, and the cooling function was activated to prevent skin surface damage.

Results: The dermal tissue temperature increased to at least 43°C during laser exposure, leading to a decrease in abdominal fat thickness after 30 days. Blood tests revealed no significant changes in kidney and liver function but showed increased blood levels of nonessential free acids (NEFAs), likely due to the release of fatty tissue-derived free fatty acids. Histological evaluation demonstrated rapid transformation of adipose tissue into collagen, muscle fibers, and intracellular fibrous tissue.

Conclusion: The 1060 nm laser showed promise as a non-invasive and safe tool for reducing abdominal fat.

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1060 nm 二极管激光器对迷你猪非侵入性皮下脂肪减少的功效

目的：评估利用波长为 1060 nm 的二极管激光减少迷你猪腹部脂肪的有效性和安全性：激光系统可非侵入性地破坏脂肪组织；其有效性和安全性通过超声波成像和组织学分析进行评估。使用不同功率的激光进行照射，并启动冷却功能以防止皮肤表面受损：结果：在激光照射过程中，真皮组织温度至少升高到 43°C，30 天后腹部脂肪厚度减少。血液检测显示肝肾功能无明显变化，但血液中的非必需游离酸（NEFAs）水平升高，这可能是由于脂肪组织游离脂肪酸的释放所致。组织学评估显示，脂肪组织迅速转化为胶原蛋白、肌肉纤维和细胞内纤维组织：结论：1060 nm 激光作为一种非侵入性的安全工具，有望减少腹部脂肪。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.