Quantitative MRI for Monitoring Metabolic Dysfunction-Associated Steatotic Liver Disease: A Test-Retest Repeatability Study.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-09-25 DOI:10.1002/jmri.29610

Cayden Beyer, Anneli Andersson, Elizabeth Shumbayawonda, Naim Alkouri, Ami Banerjee, Prashant Pandya, Mukesh Harisinghani, Kathleen Corey, Andrea Dennis, Michele Pansini

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Abstract

Background: Quantitative magnetic resonance imaging metrics iron-corrected T1 (cT1) and liver fat from proton density fat-fraction (PDFF) are both commonly used as noninvasive biomarkers for metabolic dysfunction-associated steatohepatitis (MASH); however, their repeatability in this population has rarely been characterized.

Purpose: To quantify the variability of cT1 and liver fat fraction from PDFF in patients with biopsy-confirmed metabolic dysfunction-associated steatotic liver disease (MASLD) and MASH.

Study type: Prospective, single center.

Population: Twenty-one participants (female = 11, mean age 53 ± 24 years) with biopsy-confirmed MASLD, including 6 with MASH and fibrosis ≥2.

Field strength/sequence: 3 T; T1 and T2* mapping for the generation of cT1 (shMOLLI: CardioMaps and 2D MDE, T1map-FIESTA and LMS MOST: StarMap, 2D Multi-Echo FSPGR) and magnitude-only PDFF sequence for liver fat quantification (LMS IDEAL: StarMap, 2D Multi-Echo FSPGR).

Assessment: T1 mapping and PDFF scans were performed twice on the same day for all participants (N = 21), with an additional scan 2-4 weeks later for MASH patients with fibrosis ≥2 (N = 6). Whole liver segmentation masks were generated semi-automatically and average pixel counts within these masks were used for the calculation of cT1 and liver fat fraction.

Statistical tests: Bland-Altman analysis for repeatability coefficient (RC) and 95% limits of agreement (LOA) and intraclass correlation coefficient (ICC).

Results: Same-day RC was 32.1 msec (95% LOA: -36.6 to 24.2 msec) for cT1 and 0.6% (95% LOA: -0.5% to 0.7%) for liver fat fraction; the ICCs were 0.98 (0.96-0.99) and 1.0, respectively. Short-term RC was 65.2 msec (95% LOA: -63.8 to 76.5 msec) for cT1 and 2.6% (95% LOA: -2.8% to 3.1%) for liver fat fraction.

Data conclusion: In participants with MASLD and MASH, cT1 and liver fat fraction measurements show excellent test-retest repeatability, supporting their use in monitoring MASLD and MASH.

Level of evidence: 2 TECHNICAL EFFICACY: Stage 2.

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用于监测代谢功能障碍相关性脂肪肝的定量 MRI：测试-重测重复性研究

背景：定量磁共振成像指标铁校正 T1（cT1）和质子密度脂肪分数（PDFF）显示的肝脏脂肪均常用作代谢功能障碍相关性脂肪性肝炎（MASH）的无创生物标志物；然而，它们在这一人群中的可重复性却很少被描述。目的：量化活检证实的代谢功能障碍相关性脂肪性肝病（MASLD）和MASH患者的cT1和PDFF肝脏脂肪分数的变异性：研究类型：前瞻性、单中心：21名活检证实患有代谢功能障碍相关性脂肪性肝病（MASLD）的参与者（女性=11人，平均年龄53 ± 24岁），其中6人患有MASH且肝纤维化≥2：场强/序列：3 T；用于生成 cT1 的 T1 和 T2* 映像（shMOLLI：CardioMaps 和 2D MDE，T1map-FIESTA 和 LMS MOST：StarMap，2D 多回波 FSPGR）和用于肝脏脂肪定量的纯幅度 PDFF 序列（LMS IDEAL：StarMap，2D 多回波 FSPGR）：对所有参与者（21 人）在同一天进行两次 T1 映像和 PDFF 扫描，对纤维化≥2 的 MASH 患者（6 人）在 2-4 周后再进行一次扫描。半自动生成全肝分割掩膜，掩膜内的平均像素计数用于计算 cT1 和肝脏脂肪分数：统计测试：重复性系数（RC）和 95% 一致性限值（LOA）以及类内相关系数（ICC）的 Bland-Altman 分析：cT1 和肝脂肪分数的当日重复性系数分别为 32.1 毫秒（95% LOA：-36.6 至 24.2 毫秒）和 0.6%（95% LOA：-0.5% 至 0.7%）；ICC 分别为 0.98（0.96-0.99）和 1.0。cT1 的短期 RC 为 65.2 毫秒（95% LOA：-63.8 至 76.5 毫秒），肝脏脂肪分数的短期 RC 为 2.6%（95% LOA：-2.8% 至 3.1%）：数据结论：在MASLD和MASH患者中，cT1和肝脏脂肪分数测量显示出极佳的测试重复性，支持将其用于监测MASLD和MASH。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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