Panda Rope Bridge Technique promoted Achilles tendon regeneration in a novel rat tendon defect model.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-09-29 DOI:10.1002/ksa.12490

Chen Shen, Xianding Sun, Zhi Li, Ruobin Zhang, Junlan Huang, Kaiying Tang, Ting Wang, Yangli Xie, Lin Chen, Mao Nie

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Abstract

Purpose: This study aimed to determine whether the Achilles tendon tissue can undergo the pathological process of Achilles tendon regeneration after the Panda Rope Bridge Technique (PRBT).

Methods: Rats (n = 120) that operated with Achilles tendon rupture were divided into three treatment groups: Defect group (D group), PRBT group and Defect + Fix group (DF group). The D group represented natural healing with no treatment, the PRBT group represented healing receiving PRBT treatment and the DF group represented healing through conservative treatment by ankle fixation. The morphological, histological and biomechanical properties of the defective Achilles tendon were assessed at 7, 10, 12, 14, 28 and 56 days postoperatively.

Results: Compared to that observed in the other two groups, defected rat Achilles tendons that underwent PRBT recruited more cells earlier, eventually forming mature tendons, as revealed by histological analysis. PRBT also enabled defected tendons to regain stronger mechanical properties, thereby improving the prognosis. This improvement may be related to the earlier polarization of macrophages.

Conclusion: By establishing and using a novel surgical model of Achilles tendon rupture in rats, most injured Achilles tendons can regenerate and regain normal histological properties, whereas tendons with other interventions formed fibrotic scar tissue. The strong regenerative capacity of tendon tissue enabled us to describe the pathological process of tendon regeneration after PRBT surgery in detail, which would aid in the treatment of tendon injuries. PRBT promotes Achilles tendon regeneration and has the potential to become a standard treatment.

Level of evidence: Not applicable.

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熊猫绳桥技术在新型大鼠肌腱缺损模型中促进了跟腱再生。

目的：本研究旨在确定熊猫绳桥技术（PRBT）后跟腱组织能否经历跟腱再生的病理过程：方法：将跟腱断裂的大鼠（n = 120）分为三个治疗组：缺损组（D 组）、PRBT 组和缺损 + 修复组（DF 组）。D 组代表未经治疗的自然愈合，PRBT 组代表接受 PRBT 治疗后的愈合，DF 组代表通过踝关节固定保守治疗后的愈合。在术后 7、10、12、14、28 和 56 天评估了跟腱缺损的形态学、组织学和生物力学特性：结果：组织学分析表明，与其他两组观察到的情况相比，接受 PRBT 的大鼠跟腱缺损更早地吸收了更多细胞，最终形成了成熟的肌腱。PRBT 还能使缺损肌腱恢复更强的机械性能，从而改善预后。这种改善可能与巨噬细胞较早极化有关：结论：通过建立和使用新颖的大鼠跟腱断裂手术模型，大多数受伤的跟腱都能再生并恢复正常的组织学特性，而接受其他干预的跟腱则会形成纤维化瘢痕组织。肌腱组织的强大再生能力使我们能够详细描述 PRBT 手术后肌腱再生的病理过程，这将有助于肌腱损伤的治疗。PRBT能促进跟腱再生，有望成为一种标准治疗方法：证据等级：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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