Epigenetic mechanisms in cardiovascular complications of diabetes: towards future therapies.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Medicine Pub Date : 2024-09-27 DOI:10.1186/s10020-024-00939-z

Giulia Damiano, Raffaella Rinaldi, Angela Raucci, Chiara Molinari, Annalisa Sforza, Sergio Pirola, Francesco Paneni, Stefano Genovese, Giulio Pompilio, Maria Cristina Vinci

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Abstract

The pathophysiological mechanisms of cardiovascular disease and microvascular complications in diabetes have been extensively studied, but effective methods of prevention and treatment are still lacking. In recent years, DNA methylation, histone modifications, and non-coding RNAs have arisen as possible mechanisms involved in the development, maintenance, and progression of micro- and macro-vascular complications of diabetes. Epigenetic changes have the characteristic of being heritable or deletable. For this reason, they are now being studied as a therapeutic target for the treatment of diabetes and the prevention or for slowing down its complications, aiming to alleviate the personal and social burden of the disease.This review addresses current knowledge of the pathophysiological links between diabetes and cardiovascular complications, focusing on the role of epigenetic modifications, including DNA methylation and histone modifications. In addition, although the treatment of complications of diabetes with "epidrugs" is still far from being a reality and faces several challenges, we present the most promising molecules and approaches in this field.

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糖尿病心血管并发症的表观遗传机制：迈向未来疗法。

糖尿病心血管疾病和微血管并发症的病理生理机制已被广泛研究，但仍缺乏有效的预防和治疗方法。近年来，DNA 甲基化、组蛋白修饰和非编码 RNA 成为糖尿病微血管和大血管并发症发生、维持和发展的可能机制。表观遗传变化具有可遗传或可删除的特点。因此，目前正在将表观遗传学变化作为治疗糖尿病、预防或减缓糖尿病并发症的治疗靶点进行研究，以减轻糖尿病给个人和社会带来的负担。本综述介绍了目前有关糖尿病与心血管并发症之间病理生理学联系的知识，重点是表观遗传学修饰的作用，包括 DNA 甲基化和组蛋白修饰。此外，尽管用 "表观药物 "治疗糖尿病并发症还远未成为现实，而且还面临一些挑战，但我们介绍了这一领域最有前景的分子和方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Medicine 医学-生化与分子生物学

CiteScore

8.60

自引率

0.00%

发文量

137

审稿时长

1 months

期刊介绍： Molecular Medicine is an open access journal that focuses on publishing recent findings related to disease pathogenesis at the molecular or physiological level. These insights can potentially contribute to the development of specific tools for disease diagnosis, treatment, or prevention. The journal considers manuscripts that present material pertinent to the genetic, molecular, or cellular underpinnings of critical physiological or disease processes. Submissions to Molecular Medicine are expected to elucidate the broader implications of the research findings for human disease and medicine in a manner that is accessible to a wide audience.