Per- and Polyfluoroalkyl Substances (PFAS) Affect Female Reproductive Health: Epidemiological Evidence and Underlying Mechanisms.

IF 3.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Toxics Pub Date : 2024-09-18 DOI:10.3390/toxics12090678

Rui Qu, Jingxuan Wang, Xiaojie Li, Yan Zhang, Tailang Yin, Pan Yang

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Abstract

PFAS (per- and polyfluoroalkyl substances) have been extensively used across numerous industries and consumer goods. Due to their high persistence and mobility, they are ubiquitous in the environment. Exposure to PFAS occurs in people via multiple pathways such as dermal contact, water supply, air inhalation, and dietary intake. Even if some PFAS are being phased out because of their persistent presence in the environment and harmful impacts on human health, mixes of replacement and legacy PFAS will continue to pollute the ecosystem. Numerous toxicological investigations have revealed harmful effects of PFAS exposure on female reproductive health, e.g., polycystic ovaries syndrome, premature ovarian failure, endometriosis, reproductive system tumors, pregnancy complications, and adverse pregnancy outcomes. Despite extensive epidemiological studies on the reproductive toxicity of PFAS, research findings remain inconsistent, and the underlying mechanisms are not well understood. In this review, we give an in-depth description of the sources and pathways of PFAS, and then review the reproductive toxicity of PFAS and its possible mechanisms.

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全氟和多氟烷基物质 (PFAS) 影响女性生殖健康：流行病学证据和基本机制。

PFAS（全氟烷基和多氟烷基物质）已在众多行业和消费品中广泛使用。由于具有高持久性和流动性，它们在环境中无处不在。人们会通过多种途径接触到 PFAS，如皮肤接触、供水、空气吸入和饮食摄入。即使某些 PFAS 因其在环境中的持久存在和对人类健康的有害影响而被逐步淘汰，但替代和遗留 PFAS 的混合物仍将继续污染生态系统。大量毒理学调查显示，接触全氟辛烷磺酸会对女性生殖健康产生有害影响，如多囊卵巢综合症、卵巢早衰、子宫内膜异位症、生殖系统肿瘤、妊娠并发症和不良妊娠结局。尽管对全氟辛烷磺酸的生殖毒性进行了广泛的流行病学研究，但研究结果仍不一致，对其潜在机制也不甚了解。在这篇综述中，我们将深入介绍全氟辛烷磺酸的来源和途径，然后回顾全氟辛烷磺酸的生殖毒性及其可能的机制。

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： The Journal accepts papers describing work that furthers our understanding of the exposure, effects, and risks of chemicals and materials in humans and the natural environment as well as approaches to assess and/or manage the toxicological and ecotoxicological risks of chemicals and materials. The journal covers a wide range of toxic substances, including metals, pesticides, pharmaceuticals, biocides, nanomaterials, and polymers such as micro- and mesoplastics. Toxics accepts papers covering: The occurrence, transport, and fate of chemicals and materials in different systems (e.g., food, air, water, soil); Exposure of humans and the environment to toxic chemicals and materials as well as modelling and experimental approaches for characterizing the exposure in, e.g., water, air, soil, food, and consumer products; Uptake, metabolism, and effects of chemicals and materials in a wide range of systems including in-vitro toxicological assays, aquatic and terrestrial organisms and ecosystems, model mammalian systems, and humans; Approaches to assess the risks of chemicals and materials to humans and the environment; Methodologies to eliminate or reduce the exposure of humans and the environment to toxic chemicals and materials.