Lydia Marcus Post, Dorothy R Pathak, Ann S Hamilton, Kelly A Hirko, Richard T Houang, Emily H Guseman, Dan Sanfelippo, Nicole Bohme Carnegie, L Karl Olson, Hallgeir Rui, Ann G Schwartz, Ellen M Velie
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引用次数: 0
Abstract
Background: The role of adult adiposity in young-onset breast cancer (YOBC) subtype risk is not well understood.
Methods: In this population-based case(n=1812)-control(n=1381) study of invasive YOBC (aged <50 years), cases were identified from the Los Angeles County and Metropolitan Detroit SEER registries, 2010-2015. Area-based, frequency-matched controls were sampled from the 2010 Census. General adiposity (body mass index (BMI)) and central adiposity (waist circumference (WC), waist-to-height ratio (WHtR)) across adulthood and covariates were collected from in-person interviews and measurements. Odds ratios (ORs) and 95% confidence intervals (CIs) for adiposity and YOBC tumor subtypes (i.e., luminal A, luminal B, HER2+, triple negative (TN)) were calculated, overall and by parity, using multivariable weighted logistic regression.
Results: Obese young adult BMI was inversely associated with luminal A YOBC (OR=0.35, 95% CI 0.16-0.79); other subtype associations were non-significant. Similarly, adult overweight and obese BMIs were inversely associated with luminal A (respectively OR=0.66, 95% CI 0.48-0.91 and OR=0.59, 95% CI 0.46-0.87), but not other subtypes. Conversely, larger WC was associated with higher odds of luminal B and TN YOBC (respectively OR=1.48, 95% CI 1.01-2.15 and OR=2.48, 95% CI 1.52-3.88), but not other subtypes (with similar results for WHtR); highest odds were among parous women.
Conclusions: Findings show greater general adult adiposity is associated with reduced odds of luminal A YOBC, while greater central adiposity is associated with increased odds of luminal B and TN YOBC, particularly among parous women.
Impact: Additional studies of central adiposity and YOBC subtype risk, especially incorporating pregnancy history, are warranted.
背景:成人脂肪在年轻乳腺癌(YOBC)亚型风险中的作用尚不清楚:成人脂肪在年轻乳腺癌(YOBC)亚型风险中的作用尚不十分清楚:在这项以人群为基础的病例(1812 例)-对照(1381 例)研究中,研究对象为浸润性 YOBC(年龄:20 岁 结果:肥胖的年轻成人 BMI 与管腔 A 型 YOBC 成反比:肥胖的年轻成人体重指数与管腔A型YOBC成反比(OR=0.35,95% CI 0.16-0.79);其他亚型的相关性不显著。同样,成人超重和肥胖的体重指数与管腔 A 成反比(分别为 OR=0.66,95% CI 0.48-0.91 和 OR=0.59,95% CI 0.46-0.87),但与其他亚型无关。相反,较大的腹围与较高的管腔B型和TN型YOBC几率相关(分别为OR=1.48,95% CI 1.01-2.15和OR=2.48,95% CI 1.52-3.88),但与其他亚型无关(WHtR的结果类似);奇数女性的几率最高:结论:研究结果表明,成人总体脂肪过多与管腔A型YOBC几率降低有关,而中心脂肪过多与管腔B型和TN型YOBC几率增加有关,特别是在奇偶女性中:影响:有必要对中心脂肪率和 YOBC 亚型风险进行更多研究,尤其是结合妊娠史。
期刊介绍:
Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.