{"title":"From silence to symphony: transcriptional repression and recovery in response to DNA damage.","authors":"Kamal Ajit, Monika Gullerova","doi":"10.1080/21541264.2024.2406717","DOIUrl":null,"url":null,"abstract":"<p><p>Genotoxic stress resulting from DNA damage is resolved through a signaling cascade known as the DNA Damage Response (DDR). The repair of damaged DNA is essential for cell survival, often requiring the DDR to attenuate other cellular processes such as the cell cycle, DNA replication, and transcription of genes not involved in DDR. The complex relationship between DDR and transcription has only recently been investigated. Transcription can facilitate the DDR in response to double-strand breaks (DSBs) and stimulate nucleotide excision repair (NER). However, transcription may need to be reduced to prevent potential interference with the repair machinery. In this review, we discuss various mechanisms that regulate transcription repression in response to different types of DNA damage, categorizing them by their range and duration of effect. Finally, we explore various models of transcription recovery following DNA damage-induced repression.</p>","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":null,"pages":null},"PeriodicalIF":3.6000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transcription-Austin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21541264.2024.2406717","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Genotoxic stress resulting from DNA damage is resolved through a signaling cascade known as the DNA Damage Response (DDR). The repair of damaged DNA is essential for cell survival, often requiring the DDR to attenuate other cellular processes such as the cell cycle, DNA replication, and transcription of genes not involved in DDR. The complex relationship between DDR and transcription has only recently been investigated. Transcription can facilitate the DDR in response to double-strand breaks (DSBs) and stimulate nucleotide excision repair (NER). However, transcription may need to be reduced to prevent potential interference with the repair machinery. In this review, we discuss various mechanisms that regulate transcription repression in response to different types of DNA damage, categorizing them by their range and duration of effect. Finally, we explore various models of transcription recovery following DNA damage-induced repression.
DNA 损伤导致的基因毒性应激可通过一种称为 DNA 损伤反应(DDR)的信号级联来解决。受损 DNA 的修复对细胞存活至关重要,通常需要 DDR 来减弱其他细胞过程,如细胞周期、DNA 复制和不参与 DDR 的基因转录。DDR 与转录之间的复杂关系直到最近才得到研究。转录可以促进 DDR 对双链断裂(DSB)做出反应,并刺激核苷酸切除修复(NER)。然而,转录可能需要减少,以防止对修复机制的潜在干扰。在这篇综述中,我们讨论了针对不同类型 DNA 损伤的转录抑制的各种调控机制,并根据其作用范围和持续时间进行了分类。最后,我们探讨了 DNA 损伤诱导抑制后转录恢复的各种模型。