Butin Protects Keratinocytes From Particulate Matter 2.5 and Ultraviolet B-Mediated Damages.

IF 2.5 4区医学 Q2 DERMATOLOGY Photodermatology, photoimmunology & photomedicine Pub Date : 2024-11-01 DOI:10.1111/phpp.13001

Pincha Devage Sameera Madushan Fernando, Mei Jing Piao, Kyoung Ah Kang, Herath Mudiyanselage Udari Lakmini Herath, Eui Tae Kim, Chang Lim Hyun, Young Ree Kim, Jin Won Hyun

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Abstract

Background: Butin is a naturally occurring compound with a wide range of medicinal properties, including anti-inflammatory, anti-arthritic, and antioxidant properties. Particulate matter 2.5 (PM_2.5) and ultraviolet B (UVB) radiation contribute to skin cell damage via the induction of oxidative stress.

Methods: This study sought to assess the protective effects of butin against damage triggered by PM_2.5 and UVB in human HaCaT keratinocytes. Assessments were performed to evaluate cell viability, apoptosis, and cellular component damage.

Results: Butin exhibited its protective ability via the inhibition of PM_2.5-induced reactive oxygen species generation, lipid peroxidation, DNA damage, protein carbonylation, and mitochondrial damage. Butin reduced the PM_2.5-induced c-Fos and phospho-c-Jun protein levels as well as mitogen-activated protein kinase. Furthermore, butin mitigated PM_2.5- and UVB-induced apoptosis.

Conclusion: Butin had the potential as a pharmaceutical candidate for treating skin damage caused by PM_2.5 and UVB exposure.

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丁素保护角质细胞免受微粒物质 2.5 和紫外线 B 造成的损伤

背景：丁素是一种天然化合物，具有广泛的药用特性，包括消炎、抗关节炎和抗氧化特性。颗粒物 2.5（PM2.5）和紫外线 B（UVB）辐射通过诱导氧化应激导致皮肤细胞损伤：本研究旨在评估丁素对人类 HaCaT 角质细胞中 PM2.5 和 UVB 引发的损伤的保护作用。研究评估了细胞活力、细胞凋亡和细胞成分损伤：结果：丁素通过抑制 PM2.5 诱导的活性氧生成、脂质过氧化、DNA 损伤、蛋白质羰基化和线粒体损伤来显示其保护能力。丁素降低了 PM2.5 诱导的 c-Fos、phospho-c-Jun 蛋白水平以及丝裂原活化蛋白激酶。此外，丁素还能减轻PM2.5和紫外线诱导的细胞凋亡：结论：丁素有可能成为治疗 PM2.5 和紫外线照射造成的皮肤损伤的候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodermatology, photoimmunology & photomedicine 医学-皮肤病学

CiteScore

4.40

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.