Revisiting Unaddressed Safety Concerns Regarding Intense Pulsed Light Treatment: Past and Present Perspectives.

IF 2.5 4区医学 Q2 DERMATOLOGY Photodermatology, photoimmunology & photomedicine Pub Date : 2024-11-01 DOI:10.1111/phpp.13005

Mao-Ying Lin, Tak-Wah Wong, Chrang-Shi Lin

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Abstract

Background: The light spectrum of intense pulsed light (IPL) comprises visible to near-infrared light. It has been widely employed in the field of aesthetics for approximately 30 years. However, several studies have demonstrated the appearance of various undesirable biomarkers on the skin after IPL irradiation, which remain elucidated.

Methods: We reviewed the evolving concepts and explored the potentially harmful effects of IPL that may have been neglected in the past.

Results: Increased levels of reactive oxidative stress, p53, p16, proliferating cell nuclear antigen, interleukin-6, C-reactive protein, and cleaved caspase 3 and decreased albumin levels in human or mouse skin have been observed after IPL treatment. Visible and infrared light can exert harmful and beneficial effects on human skin.

Conclusion: If perform improperly, IPL treatment may lead to cellular senescence, photoaging, photocarcinogenesis, thermal aging, and inflammaging. Further studies are required to verify the significance of the changes in the relevant biomarkers. The selection of treatment candidates, optimal parameters, and standardized protocols for IPL therapy are necessary.

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重新审视尚未解决的强脉冲光治疗安全问题：过去和现在的观点。

背景：强脉冲光（IPL）的光谱由可见光到近红外线组成。近 30 年来，强脉冲光一直被广泛应用于美容领域。然而，多项研究表明，强脉冲光照射后皮肤上会出现各种不良的生物标记物，这些标记物仍有待阐明：我们回顾了不断发展的概念，并探讨了过去可能被忽视的 IPL 潜在有害影响：结果：经强脉冲光照射后，在人类或小鼠皮肤中观察到活性氧化应激、p53、p16、增殖细胞核抗原、白细胞介素-6、C 反应蛋白和裂解的 Caspase 3 水平升高，白蛋白水平降低。可见光和红外线可对人体皮肤产生有害和有益的影响：如果操作不当，强脉冲光治疗可能会导致细胞衰老、光老化、光致癌、热老化和炎症老化。要验证相关生物标志物变化的意义，还需要进一步的研究。有必要为 IPL 治疗选择治疗对象、最佳参数和标准化方案。

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来源期刊

Photodermatology, photoimmunology & photomedicine 医学-皮肤病学

CiteScore

4.40

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.