Chest CT assess the impact of omalizumab treatment on airway remodeling in refractory asthma

IF 3.3 3区 医学 Q2 PHARMACOLOGY & PHARMACY Pulmonary pharmacology & therapeutics Pub Date : 2024-10-03 DOI:10.1016/j.pupt.2024.102329
Honglei Shi , Zehu Chen , Qianqian Lei , Donghai Ma , Meizhu Chen , Jing Liu
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Abstract

Background

To evaluate the benefits of omalizumab treatment in patients through real-world follow-up and assess the impact of omalizumab treatment on airway remodeling using chest CT.

Methods

This is a single-center prospective, observational study included Chinese patients with refractory asthma who received omalizumab treatment from May 2021 to December 2022. We collected real-world clinical data, including their hospitalization information, pulmonary function, FENO, laboratory assessment, ACT scores, chest CT at baseline and every follow-up month. A comparison was made between the pre-treatment and post-treatment laboratory indicators, pulmonary function, airway parameters, and mucous plug scores under chest CT.

Results

This study included a total of 61 patients with refractory asthma treated with omalizumab. The study found that: ①regardless of whether the treatment lasted for a full four months or not, it significantly improved patient asthma control scores and reduced hospitalization costs and length of stay (p < 0.05). ②After four months of treatment, pulmonary ventilation function examination revealed significant improvements (p < 0.05) in MEF75, MEF50, MEF75/25, PEF, and FEV1/FVC. ③After four months of omalizumab treatment, the ratio of wall thickness and outer radius (T/D) and wall area percentage (WA%) of the bronchial wall decreased significantly (p < 0.05). ④After medication, the expression of airway mucous plugs decreased.

Conclusions

Omalizumab treatment can reduce airway wall thickness, decrease the percentage of airway wall area, and the expression of airway mucous plugs, thereby improving airflow limitation. Utilizing chest CT provides a novel and intuitive assessment of the efficacy of omalizumab treatment.

Trial registration

This study was registered in Chinese Clinical Trial Registry, the number is ChiCTR2100046343.
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胸部 CT 评估奥马珠单抗治疗对难治性哮喘患者气道重塑的影响。
背景:通过实际随访评估奥马珠单抗治疗对患者的益处,并使用胸部 CT 评估奥马珠单抗治疗对气道重塑的影响:通过真实世界随访评估奥马珠单抗治疗对患者的益处,并使用胸部CT评估奥马珠单抗治疗对气道重塑的影响:这是一项单中心前瞻性观察研究,纳入了2021年5月至2022年12月期间接受奥马珠单抗治疗的中国难治性哮喘患者。我们收集了真实世界的临床数据,包括基线和每个随访月的住院信息、肺功能、FENO、实验室评估、ACT评分、胸部CT。对治疗前和治疗后的实验室指标、肺功能、气道参数和胸部 CT 下的粘液栓塞评分进行比较:本研究共纳入了 61 名接受奥马珠单抗治疗的难治性哮喘患者。研究发现无论治疗是否持续满四个月,都能显著改善患者的哮喘控制评分,减少住院费用和住院时间(p结论:奥马珠单抗治疗可减少哮喘患者的住院费用和住院时间:奥马珠单抗治疗可减少气道壁厚度、降低气道壁面积百分比和气道粘液栓的表达,从而改善气流受限。利用胸部 CT 可以对奥马珠单抗的疗效进行新颖、直观的评估:本研究已在中国临床试验注册中心注册,注册号为ChiCTR2100046343。
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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
41
审稿时长
42 days
期刊介绍: Pulmonary Pharmacology and Therapeutics (formerly Pulmonary Pharmacology) is concerned with lung pharmacology from molecular to clinical aspects. The subject matter encompasses the major diseases of the lung including asthma, cystic fibrosis, pulmonary circulation, ARDS, carcinoma, bronchitis, emphysema and drug delivery. Laboratory and clinical research on man and animals will be considered including studies related to chemotherapy of cancer, tuberculosis and infection. In addition to original research papers the journal will include review articles and book reviews. Research Areas Include: • All major diseases of the lung • Physiology • Pathology • Drug delivery • Metabolism • Pulmonary Toxicology.
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