Association of Short Sleep Duration and Obstructive Sleep Apnea with Central Obesity: A Retrospective Study Utilizing Anthropometric Measures.

IF 3 2区医学 Q2 CLINICAL NEUROLOGY Nature and Science of Sleep Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI:10.2147/NSS.S483984

Yi Li, Yixuan Lu, Youdan Zhao, Zhi Lyu

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Abstract

Background: Central obesity, as measured by examination instruments, has been shown to be associated with both OSA and short sleep duration. However, objective measurement tools like CT, MRI, and DXA are expensive, cause radiation exposure, and have limited availability, especially in resource-limited settings. Thus, this study aimed to demonstrate the relevance of Body Mass Index (BMI) and Waist-to-Height Ratio (WHtR) as surrogate indicators of visceral obesity in the assessment of OSA and short sleep duration. We also intend to evaluate whether WHtR, in combination with BMI, can be a suitable surrogate marker for visceral adiposity.

Methods: We recruited 333 adults with complete polysomnographic (PSG) records retrospectively. Logistic regression helped to assess the association of BMI and WHtR as surrogates for central adiposity with OSA and short sleep duration. Moreover, ROC curve analysis was conducted to evaluate the predictive ability of BMI and WHtR.

Results: Following the relevant adjustments, logistic regression analysis results showed that the combination of WHtR and BMI acting as central obesity surrogates was significantly associated with OSA and short sleep duration (p<0.05). According to univariate regression analysis, sleep latency and wake after sleep onset were independent predictors of the risk of central obesity in patients with short sleep duration and OSA. Additionally, ROC curve analysis demonstrated that the combination of BMI and WHtR provided a better assessment of central adiposity in patients with OSA and short sleep duration, compared to each measure alone.

Conclusion: BMI and WHtR are significantly associated with OSA and short sleep duration, and might serve as a potential surrogate marker for central obesity. Sleep latency and wake after sleep onset can independently predict the risk of central obesity in patients with short sleep time and OSA. Thus, larger prospective studies are needed to verify our findings.

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睡眠时间短和阻塞性睡眠呼吸暂停与中心性肥胖的关系：利用人体测量法进行的回顾性研究

背景：通过检查仪器测量的中心性肥胖已被证明与 OSA 和睡眠时间短有关。然而，CT、MRI 和 DXA 等客观测量工具价格昂贵，会产生辐射，而且可用性有限，尤其是在资源有限的环境中。因此，本研究旨在证明身体质量指数（BMI）和腰围身高比（WHtR）作为内脏肥胖的替代指标在评估 OSA 和睡眠时间短中的相关性。我们还打算评估 WHtR 与体重指数相结合是否能成为内脏肥胖的替代指标：方法：我们招募了333名具有完整多导睡眠图（PSG）记录的成年人。逻辑回归有助于评估作为中枢性脂肪替代指标的体重指数和 WHtR 与 OSA 和睡眠时间短的关系。此外，还进行了 ROC 曲线分析，以评估 BMI 和 WHtR 的预测能力：结果：经过相关调整后，逻辑回归分析结果显示，作为中心性肥胖代用指标的 WHtR 和 BMI 组合与 OSA 和睡眠时间短显著相关（p 结论：BMI 和 WHtR 与 OSA 和睡眠时间短显著相关：BMI和WHtR与OSA和睡眠时间短显著相关，可作为中心性肥胖的潜在替代指标。睡眠潜伏期和睡眠开始后唤醒可独立预测睡眠时间短和 OSA 患者的中心性肥胖风险。因此，需要更大规模的前瞻性研究来验证我们的发现。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.