Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study.

IF 3 2区医学 Q2 CLINICAL NEUROLOGY Nature and Science of Sleep Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI:10.2147/NSS.S488911

Hao-Bo Chen, Ling Li, Yun-Kai Sun, Yi Liu, Wei Chen, Peng Liu, Yan-Hui Liao, An Xie

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Abstract

Background: COVID-19 has led to reports of fatigue and sleep problems. Brain function changes underlying sleep problems (SP) post-COVID-19 are unclear.

Purpose: This study investigated SP-related brain functional connectivity (FC) alterations.

Patients and methods: Fifty-five COVID-19 survivors with SP (COVID_SP) and 33 without SP (COVID_NSP), matched for demographics, completed PSQI and underwent rs-fMRI at baseline and 2-month follow-up. Correlations between FC and clinical data were analyzed by Pearson correlation analysis with Gaussian random field (GRF) correction. The repeated-measures analysis of variance (R-M ANOVA) was completed to explore the interaction with time.

Results: At baseline, COVID_SP exhibited elevated FC: right precentral gyrus (PrG) with left lateral occipital cortex (LOcC)/right PrG, left inferior parietal lobule (IPL) with right superior frontal gyrus (SFG), left hippocampus with right inferior frontal gyrus (IFG). Higher FC between left hippocampus and right SFG correlated with PSQI scores. At 2-month follow-up, decreased FC implicated in emotion regulation, executive function, and memory; increased FC in semantics, attention, and auditory-visual processing. The changes in these regions are correlated with the scores of PSQI, GAD, and PHQ. The Repeated-Measures Analysis of Variance (R-M ANOVA) revealed a significant time interaction effect between sleep and various emotion scales. Moreover, the analysis of the functional connectivity between the right PrG and the right PrG as well as that between the left IPL and the right SFG also discovered a significant time interaction effect.

Conclusion: This study provides insight into the changes in brain function associated with SP after COVID-19. These changes may partially explain the development of SP, and they also changed over time.

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与covid -19相关睡眠问题相关的功能连接改变：一项纵向静息状态功能磁共振成像研究

背景：COVID-19导致了疲劳和睡眠问题的报告。新冠肺炎后睡眠问题（SP）背后的大脑功能变化尚不清楚。目的：研究sp相关的脑功能连接（FC）改变。患者和方法：55名患有SP （COVID_SP）和33名未患有SP （COVID_NSP）的COVID-19幸存者，人口统计学匹配，完成PSQI并在基线和2个月随访时接受rs-fMRI。采用Pearson相关分析和高斯随机场（GRF）校正分析FC与临床资料的相关性。采用重复测量方差分析（R-M ANOVA）探讨其与时间的相互作用。结果：在基线时，COVID_SP表现出升高的FC：右侧中央前回（PrG）与左侧枕叶外侧皮层(LOcC)/右侧PrG，左侧顶叶下小叶（IPL）与右侧额上回（SFG），左侧海马与右侧额下回（IFG）。左侧海马体和右侧SFG间FC升高与PSQI评分相关。在2个月的随访中，与情绪调节、执行功能和记忆有关的FC减少；语义、注意力和视听处理的FC增加。这些区域的变化与PSQI、GAD和PHQ得分相关。重复测量方差分析（R-M ANOVA）显示睡眠与各种情绪量表之间存在显著的时间交互效应。此外，右PrG与右PrG、左IPL与右SFG之间的功能连通性分析也发现了显著的时间相互作用效应。结论：本研究揭示了新冠肺炎后SP相关的脑功能变化。这些变化可能部分解释了SP的发展，它们也随着时间的推移而变化。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.