Caspase-8 in inflammatory diseases: a potential therapeutic target.

IF 9.2 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cellular & Molecular Biology Letters Pub Date : 2024-10-08 DOI:10.1186/s11658-024-00646-x
Wangzheqi Zhang, Chenglong Zhu, Yan Liao, Miao Zhou, Wenyun Xu, Zui Zou
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Abstract

Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for its regulatory role in extrinsic apoptosis. With advancing research, a growing body of evidence has substantiated its involvement in other cell death processes, such as pyroptosis and necroptosis, as well as its modulatory effects on inflammasomes and proinflammatory cytokines. PANoptosis, an emerging concept of cell death, encompasses pyroptosis, apoptosis, and necroptosis, providing insight into the often overlapping cellular mortality observed during disease progression. The activation or deficiency of caspase-8 enzymatic activity is closely linked to PANoptosis, positioning caspase-8 as a key regulator of cell survival or death across various physiological and pathological processes. Aberrant expression of caspase-8 is closely associated with the development and progression of a range of inflammatory diseases, including immune system disorders, neurodegenerative diseases (NDDs), sepsis, and cancer. This paper delves into the regulatory role and impact of caspase-8 in these conditions, aiming to elucidate potential therapeutic strategies for the future intervention.

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炎症性疾病中的 Caspase-8:潜在的治疗目标。
Caspase-8 是酶家族中著名的半胱氨酸-天冬氨酸蛋白酶,最初因其在细胞外凋亡中的调控作用而备受关注。随着研究的不断深入,越来越多的证据证明它参与了其他细胞死亡过程,如热凋亡和坏死,以及它对炎性体和促炎细胞因子的调节作用。细胞凋亡(PANoptosis)是一个新出现的细胞死亡概念,它包括热凋亡、细胞凋亡和坏死,使人们对疾病进展过程中经常出现的重叠细胞死亡现象有了更深入的了解。caspase-8酶活性的激活或缺乏与细胞凋亡密切相关,这使得caspase-8成为各种生理和病理过程中细胞存活或死亡的关键调节因子。caspase-8 的异常表达与一系列炎症性疾病的发生和发展密切相关,包括免疫系统疾病、神经退行性疾病(NDDs)、败血症和癌症。本文深入探讨了 caspase-8 在这些疾病中的调控作用和影响,旨在阐明未来干预的潜在治疗策略。
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来源期刊
Cellular & Molecular Biology Letters
Cellular & Molecular Biology Letters 生物-生化与分子生物学
CiteScore
11.60
自引率
13.30%
发文量
101
审稿时长
3 months
期刊介绍: Cellular & Molecular Biology Letters is an international journal dedicated to the dissemination of fundamental knowledge in all areas of cellular and molecular biology, cancer cell biology, and certain aspects of biochemistry, biophysics and biotechnology.
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