Oxygen uptake efficiency slope at anaerobic threshold can predict peak VO2 in adult congenital heart disease

IF 0.8 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS International journal of cardiology. Congenital heart disease Pub Date : 2024-09-29 DOI:10.1016/j.ijcchd.2024.100546
{"title":"Oxygen uptake efficiency slope at anaerobic threshold can predict peak VO2 in adult congenital heart disease","authors":"","doi":"10.1016/j.ijcchd.2024.100546","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Assessment of exercise capacity by cardiopulmonary exercise testing (CPET) in adults with congenital heart disease (CHD) is important for prognostication and preoperative assessment. Peak oxygen uptake (PVO<sub>2</sub>) is used commonly, but can be challenging due to the difficulties of undertaking maximal CPET testing in this population. We explored whether oxygen uptake efficiency slope (OUES) at ventilatory anaerobic threshold (VAT), the point during CPET at which OUES becomes strongly correlated with PVO<sub>2</sub>, and is more reliably available from submaximal CPET, can predict PVO<sub>2</sub> in adults with CHD.</div></div><div><h3>Methods</h3><div>We assessed consecutive individuals who completed maximal CPET at our cardiorespiratory centre, as part of routine service review, between March 2019 and August 2021, recording data such as PVO<sub>2</sub>, VAT and OUES at various proportions of a maximal test (75 %, 90 %, 100 %, and VAT). We employed linear regression modelling to analyse the association between PVO<sub>2</sub> and OUES at VAT, and subsequently create an equation to predict PVO<sub>2</sub> from OUES at VAT. Parametric data are presented using Pearson's correlation coefficient and non-parametric data using Spearman's rho.</div></div><div><h3>Results</h3><div>We analysed 391 individuals (177 female, age 32 ± 11 years). Mean ± SD PVO<sub>2</sub> was 23.3 ± 6.86 ml/min/kg or 1724 ± 540 ml/min, peak VE 86.7 ± 25.4 l/min. The point of VAT as a percentage of PVO<sub>2</sub> achieved was 66.5 ± 9.4 %, and VAT as a percentage of predicted PVO<sub>2</sub> 46.9 ± 11.4 %. PVO<sub>2</sub> was correlated with OUES at 100 % (R = 0.91, P &lt; .001), 90 % (R = 0.91, P &lt; .001), 75 % (R = 0.89, P &lt; .001) of maximum, and VAT (R = 0.83, P &lt; .001). PVO<sub>2</sub> <em>(ml/min)</em> could be predicted by: <em>(OUES at VAT)∗685.245 + (BMI [kg/m</em><sup><em>2</em></sup><em>])∗5.045 + (FEV</em><sub><em>1</em></sub> <em>[l])∗223.620 – 153.205</em>.</div></div><div><h3>Conclusions</h3><div>OUES at VAT can be used to calculate PVO<sub>2</sub>. To our knowledge, this is the first equation using OUES at VAT to predict PVO<sub>2</sub> in adults with CHD. In a population who may find maximal CPET difficult, this may be a useful submaximal measurement of cardiovascular fitness, and to calculate PVO<sub>2</sub>, which is commonly used in guideline-based decision making in CHD.</div></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of cardiology. Congenital heart disease","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666668524000557","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction

Assessment of exercise capacity by cardiopulmonary exercise testing (CPET) in adults with congenital heart disease (CHD) is important for prognostication and preoperative assessment. Peak oxygen uptake (PVO2) is used commonly, but can be challenging due to the difficulties of undertaking maximal CPET testing in this population. We explored whether oxygen uptake efficiency slope (OUES) at ventilatory anaerobic threshold (VAT), the point during CPET at which OUES becomes strongly correlated with PVO2, and is more reliably available from submaximal CPET, can predict PVO2 in adults with CHD.

Methods

We assessed consecutive individuals who completed maximal CPET at our cardiorespiratory centre, as part of routine service review, between March 2019 and August 2021, recording data such as PVO2, VAT and OUES at various proportions of a maximal test (75 %, 90 %, 100 %, and VAT). We employed linear regression modelling to analyse the association between PVO2 and OUES at VAT, and subsequently create an equation to predict PVO2 from OUES at VAT. Parametric data are presented using Pearson's correlation coefficient and non-parametric data using Spearman's rho.

Results

We analysed 391 individuals (177 female, age 32 ± 11 years). Mean ± SD PVO2 was 23.3 ± 6.86 ml/min/kg or 1724 ± 540 ml/min, peak VE 86.7 ± 25.4 l/min. The point of VAT as a percentage of PVO2 achieved was 66.5 ± 9.4 %, and VAT as a percentage of predicted PVO2 46.9 ± 11.4 %. PVO2 was correlated with OUES at 100 % (R = 0.91, P < .001), 90 % (R = 0.91, P < .001), 75 % (R = 0.89, P < .001) of maximum, and VAT (R = 0.83, P < .001). PVO2 (ml/min) could be predicted by: (OUES at VAT)∗685.245 + (BMI [kg/m2])∗5.045 + (FEV1 [l])∗223.620 – 153.205.

Conclusions

OUES at VAT can be used to calculate PVO2. To our knowledge, this is the first equation using OUES at VAT to predict PVO2 in adults with CHD. In a population who may find maximal CPET difficult, this may be a useful submaximal measurement of cardiovascular fitness, and to calculate PVO2, which is commonly used in guideline-based decision making in CHD.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
无氧阈值时的摄氧量效率斜率可预测成人先天性心脏病患者的 VO2 峰值
导言:通过心肺运动测试(CPET)评估先天性心脏病(CHD)成人患者的运动能力对于预后和术前评估非常重要。峰值摄氧量(PVO2)是常用的方法,但由于在这类人群中进行最大 CPET 测试存在困难,因此具有挑战性。我们探讨了通气无氧阈值(VAT)时的摄氧效率斜率(OUES)是否能预测患有冠心病的成人的 PVO2,在 CPET 测试过程中,OUES 与 PVO2 密切相关,而且亚最大 CPET 测试更可靠。方法我们评估了 2019 年 3 月至 2021 年 8 月期间在我们的心肺中心完成最大 CPET 的连续患者,作为常规服务审查的一部分,记录了最大测试不同比例(75%、90%、100% 和 VAT)的 PVO2、VAT 和 OUES 等数据。我们采用线性回归模型来分析 VAT 时 PVO2 和 OUES 之间的关联,并随后创建了一个方程,根据 VAT 时的 OUES 预测 PVO2。参数数据使用皮尔逊相关系数表示,非参数数据使用斯皮尔曼 rho 表示。平均 ± SD PVO2 为 23.3 ± 6.86 毫升/分钟/公斤或 1724 ± 540 毫升/分钟,峰值 VE 为 86.7 ± 25.4 升/分钟。VAT 点占达到的 PVO2 的百分比为 66.5 ± 9.4 %,占预测 PVO2 的百分比为 46.9 ± 11.4 %。PVO2 与最大值的 100 %(R = 0.91,P < .001)、90 %(R = 0.91,P < .001)、75 %(R = 0.89,P < .001)和 VAT 的 OUES 相关(R = 0.83,P < .001)。PVO2(毫升/分钟)可通过以下方式预测:(VAT 时的 OUES)∗685.245 + (BMI [kg/m2])∗5.045 + (FEV1 [l])∗223.620 - 153.205。据我们所知,这是第一个使用脉宽处的 OUES 预测患有心脏病的成人 PVO2 的公式。对于难以进行最大 CPET 的人群来说,这可能是一种有用的心血管健康亚极限测量方法,并可用于计算 PVO2,而 PVO2 通常用于基于指南的心脏病决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
International journal of cardiology. Congenital heart disease
International journal of cardiology. Congenital heart disease Cardiology and Cardiovascular Medicine
自引率
0.00%
发文量
0
审稿时长
83 days
期刊最新文献
Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries Segmental MRI pituitary and hypothalamus volumes post Fontan: An analysis of the Australian and New Zealand Fontan registry Infective endocarditis: Awareness, knowledge gaps and behaviours amongst adults with congenital heart disease Comparative analysis of diagnostic accuracy in adult congenital heart disease: A study of three physician groups and ChatGPT Oxygen uptake efficiency slope at anaerobic threshold can predict peak VO2 in adult congenital heart disease
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1