International journal of cardiology. Congenital heart disease最新文献

英文中文

The utility of 4D intracardiac echocardiography in transcatheter pulmonary valve replacement in adult congenital heart disease patients 4D心内超声心动图在成人先天性心脏病经导管肺瓣膜置换术中的应用

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology. Congenital heart disease

Pub Date : 2026-01-06 DOI: 10.1016/j.ijcchd.2026.100652

Eihab Ghantous , Hans Gao , Carlos Sisniega , Angela Li , Jamil Aboulhosn

Background

Intracardiac echocardiography (ICE) has become a critical imaging modality in adult congenital heart disease (ACHD) interventions, offering high-resolution intracardiac imaging without the need for intubation. In transcatheter pulmonary valve replacement (TCPVR), ICE may overcome limitations of traditional imaging, particularly in visualizing the right ventricular outflow tract (RVOT) and pulmonary valve.

Objectives

This study aimed to evaluate the feasibility, safety, and clinical utility of four-dimensional (4D) ICE in ACHD patients undergoing TCPVR.

Methods

Beginning in February 2023, we prospectively enrolled all patients undergoing TCPVR at a tertiary ACHD center. Patients underwent preprocedural imaging and clinical evaluation. 4D ICE was used pre- and post-valve implantation to assess cardiac anatomy and valve function. Patients without valve implantation or 4D ICE imaging were excluded.

Results

Of 55 referred patients, 45 underwent successful TCPVR with 4D ICE. The mean age was 42.6 ± 13.6 years, and 51 % were male. 4D ICE confirmed procedural indications, provided comprehensive anatomic and functional assessment, and detected post-implantation regurgitation in 35.6 % of cases, significantly more than angiography (11.1 %) or transthoracic echocardiography (4.4 %). Incidental but clinically relevant findings were identified in 33.3 % of patients, influencing management in 15.6 %. No ICE-related complications occurred.

Conclusions

4D ICE is a feasible, safe, and clinically valuable imaging tool during TCPVR in ACHD patients. It enhances procedural guidance, detects early valve-related complications, and identifies unexpected findings that affect management. Its integration into structural heart interventions may significantly improve outcomes, especially as technology continues to evolve.

心内超声心动图（ICE）已成为成人先天性心脏病（ACHD）干预的关键成像方式，无需插管即可提供高分辨率的心内成像。在经导管肺瓣膜置换术（TCPVR）中，ICE可以克服传统成像的局限性，特别是在显示右心室流出道（RVOT）和肺瓣膜方面。目的本研究旨在评估四维（4D） ICE在ACHD患者行TCPVR的可行性、安全性和临床应用。方法：从2023年2月开始，我们前瞻性地招募了所有在三级ACHD中心接受TCPVR的患者。患者接受术前影像学检查和临床评估。在瓣膜植入前后应用4D ICE评估心脏解剖和瓣膜功能。没有瓣膜植入或4D ICE成像的患者被排除在外。结果55例患者中，45例成功行TCPVR + 4D ICE。平均年龄42.6±13.6岁，男性占51%。4D ICE证实了手术指征，提供了全面的解剖和功能评估，35.6%的病例发现了植入后反流，明显高于血管造影（11.1%）或经胸超声心动图（4.4%）。在33.3%的患者中发现了偶然但与临床相关的发现，15.6%的患者影响了治疗。无ice相关并发症发生。结论4d ICE是一种可行、安全、有临床价值的成像工具。它加强了手术指导，发现早期与瓣膜相关的并发症，并识别影响管理的意外发现。将其整合到结构性心脏干预中可能会显著改善结果，特别是随着技术的不断发展。

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引用次数: 0

Strength and resistance training in adult congenital heart disease: A guide to exercise prescription in the clinic 成人先天性心脏病的力量和阻力训练：临床运动处方指南

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology. Congenital heart disease

Pub Date : 2025-12-27 DOI: 10.1016/j.ijcchd.2025.100650

Calum Dolan , Gemma Brown , Elaine Muirhead , Lorna Swan

引用次数: 0

Biventricular remodeling and function after Cone repair of Ebstein Anomaly: A review Ebstein异常椎体修复后双心室重构及功能的研究进展

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology. Congenital heart disease

Pub Date : 2025-12-24 DOI: 10.1016/j.ijcchd.2025.100649

Mimi X. Deng , Alison J. Howell , Osami Honjo , Mark K. Friedberg

The Cone reconstruction is the prevailing repair strategy for Ebstein anomaly (EA), providing near-anatomical restoration of the tricuspid valve (TV) and reliable reduction of tricuspid regurgitation (TR). Most of the risk of Cone repair is seen in the early postoperative period from dehiscence, with very low rates of mortality and reintervention thereafter. By correcting TV dysfunction and abnormal right ventricle (RV) geometry, ventricular reverse remodeling has been demonstrated through decreased right atrial and atrialized RV size, along with improved antegrade pulmonary flow and consequent left ventricular filling. Early postoperative RV dysfunction is common due to increased afterload upon addressing TR, with suggestion of delayed recovery. Cone repair augments left ventricular preload and preserves left ventricular function. The contrasting effects of ventricular plication and superior repositioning of TV during the Cone repair has led to discrepant reports in the trajectory of RV remodeling, which is further confounded by the lack of standardization in imaging measurements and timing of surveillance. Consistency in imaging protocol and lengthening follow-up will hopefully provide a more robust understanding about the evolution of the postoperative RV. Improvement in functional status and aerobic capacity can also be appreciated post-Cone repair, particularly in highly symptomatic patients. Innovation to promote remodeling of the Ebsteinoid heart include stem cell therapy at the time of surgical repair, which has shown promise in phase I clinical trial. Lastly, the goal of biventricular repair through Cone reconstruction can be facilitated by Starnes palliation to stabilize critical presentations, a paradigm shift that is increasingly adopted.

锥体重建是Ebstein畸形（EA）的主流修复策略，提供三尖瓣（TV）的接近解剖的修复和可靠的三尖瓣反流（TR）的减少。椎体修复的大部分风险发生在术后早期，因为椎体破裂，死亡率和此后的再干预率非常低。通过纠正TV功能障碍和右心室（RV）几何形状异常，右心房和心房化右心室尺寸减小，顺行肺血流改善，左心室充盈，证明了心室反向重构。术后早期右心室功能障碍是常见的，因为处理TR后负荷增加，提示恢复延迟。锥体修复增强左心室预负荷，保留左心室功能。在椎体修复过程中，心室收缩和电视复位的不同效果导致了RV重构轨迹的不同报道，这进一步被成像测量和监测时间缺乏标准化所混淆。成像方案的一致性和延长随访有望提供对术后右心室演变的更有力的了解。椎体修复后功能状态和有氧能力的改善也值得赞赏，特别是在症状严重的患者中。促进Ebsteinoid心脏重塑的创新包括手术修复时的干细胞治疗，这在I期临床试验中显示出希望。最后，通过椎体重建实现双心室修复的目标可以通过Starnes姑息治疗来稳定关键的表现，这是一种越来越被采用的范式转变。

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引用次数: 0

Outcome of ventricular assist devices in adults with congenital heart disease – A single center case series 成人先天性心脏病患者心室辅助装置的疗效-单中心病例系列

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology. Congenital heart disease

Pub Date : 2025-12-20 DOI: 10.1016/j.ijcchd.2025.100648

Ahmed Younis , Zeyad M. Kholeif , William R. Miranda , Heidi M. Connolly , Mauricio T. Villavicencio , Joseph A. Dearani , Alexander C. Egbe

引用次数: 0

Progression of stenosis severity and aortopathy in adult patients with congenital aortic stenosis 成人先天性主动脉狭窄患者的狭窄严重程度和主动脉病变进展

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology. Congenital heart disease

Pub Date : 2025-12-16 DOI: 10.1016/j.ijcchd.2025.100646

Zoë A. Keuning , Frederike Meccanici , Kevin M. Veen , Bibi Schreurs , Roland R.J. van Kimmenade , Joost P. van Melle , Monique R.M. Jongbloed , Michiel Voskuil , Berto J. Bouma , Famke Sneep , Jeroen F.A. Simons , Alexander Hirsch , Jolien W. Roos-Hesselink , Annemien E. van den Bosch

Background

Congenital aortic stenosis (AS) is a heterogeneous disease. However, repeated data describing disease progression is limited, especially in adults. Therefore, the objective of this study is to investigate progression of peak velocity and aortic dimensions in adult congenital AS patients, identifying markers for fast progression.

Methods

Adult patients (aged 18–55 years) with a native aortic valve and at least mild AS at baseline registered in the Dutch CONCOR registry between 2001 and 2019 from all six tertiary expert centers for congenital heart disease were included. Patients with severe aortic regurgitation at baseline or no available echocardiograms during follow-up were excluded. Data on ascending aortic dimensions and peak velocity changes over time were analyzed using mixed models until death, aortic valve replacement or March 1, 2023.

Results

402 patients (63 % male) were included with a median age of 26 [IQR 19–41] years and peak velocity of 3.1 [IQR 2.7–3.6] m/s. Median follow-up time was 6.8 [IQR 3.8–11.6] years. Peak velocity significantly progressed over time with 0.06 ± 0.10 m/s/year (p < 0.001), independent of baseline velocity. Older age and concentric left ventricular (LV) remodeling were associated with faster progression. Mean progression of ascending aortic dimension was 0.4 ± 0.5 mm/year (p < 0.001), with faster progression in younger patients (p = 0.002). No correlation between aortic growth rate and stenosis severity progression was seen (r = 0.001, p = 0.98).

Conclusion

Overall disease progression was slow in adult congenital AS patients, and independent of baseline peak velocity. Progression of stenosis should be monitored more carefully in older patients and patients with signs of concentric LV remodeling.

背景先天性主动脉瓣狭窄（AS）是一种异质性疾病。然而，描述疾病进展的重复数据有限，特别是在成人中。因此，本研究的目的是研究成人先天性AS患者的峰值流速和主动脉尺寸的进展，确定快速进展的标志物。方法纳入2001年至2019年期间在荷兰CONCOR登记的所有六个先天性心脏病三级专家中心登记的具有天然主动脉瓣且基线时至少轻度AS的成年患者（18-55岁）。排除基线时有严重主动脉反流或随访时无超声心动图的患者。使用混合模型分析升主动脉尺寸和峰值流速随时间变化的数据，直到死亡、主动脉瓣置换术或2023年3月1日。结果402例患者（63%为男性），中位年龄26 [IQR 19-41]岁，峰值流速3.1 [IQR 2.7-3.6] m/s。中位随访时间为6.8年[IQR 3.8 ~ 11.6]年。峰值速度随时间显著增加，为0.06±0.10 m/s/年（p < 0.001），与基线速度无关。年龄越大，左室同心重构越快。升主动脉直径的平均进展为0.4±0.5 mm/年（p < 0.001），年轻患者的进展更快（p = 0.002）。主动脉生长速率与狭窄严重程度进展无相关性（r = 0.001, p = 0.98）。结论成人先天性AS患者总体病情进展缓慢，且与基线峰值速度无关。老年患者和有同心性左室重构迹象的患者应更仔细地监测狭窄的进展。

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引用次数: 0

Last of the Eisenmengers: A Tribute 最后的艾森曼格：致敬

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology. Congenital heart disease

Pub Date : 2025-12-05 DOI: 10.1016/j.ijcchd.2025.100645

Craig Broberg

引用次数: 0

Percutaneous closure of perimembranous and infundibular ventricular septal defects: single-center experience in 203 patients with medium- and long-term follow-up 经皮膜周和小室间隔缺损闭合：203例中长期随访患者的单中心经验

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology. Congenital heart disease

Pub Date : 2025-12-01 DOI: 10.1016/j.ijcchd.2025.100641

Nataliia Yashchuk , Igor Ditkivskyy , Denys Voloshyn , Bogdan Cherpak , Yuliia Yermolovych

引用次数: 0

Prognostic implications of heart failure rehospitalization in adults with CHD & clinical benefits of medical therapy 成人冠心病患者心力衰竭再住院的预后意义及药物治疗的临床益处

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology. Congenital heart disease

Pub Date : 2025-12-01 DOI: 10.1016/j.ijcchd.2025.100640

Emili P. Rosado Rodriguez, Cynthia S. Crowson, Alexander C. Egbe

Background

The risk factors for heart failure (HF) rehospitalization, and the effect of guideline directed medical therapy (GDMT) are poorly understood in adults with congenital heart disease (ACHD). We aimed to describe the outcomes of HF hospitalization and to assess the clinical benefits of GDMT for HF.

Methods

We conducted a retrospective cohort study of ACHD hospitalized for HF at Mayo Clinic from 2003 to 2023. Cox proportional hazard models were used to determine the predictors of HF rehospitalization and all-cause mortality, and to assess the association between death and GDMT, as measured by the Heart Failure Collaborative score.

Results

Of the 324 patients, 164 were rehospitalized for HF and 149 died. The 10-year cumulative incidence of rehospitalization was 75.8 % (95 % CI 70.1 %–81.5 %), and the 10-year survival rate from mortality was 47.3 % (95 % CI 40.9 %–54.7 %). Chronic kidney disease (HR 1.46, 95 % CI 1.06–2.01, p = 0.021) and Fontan physiology (HR 1.59, 95 % CI 1.02–2.49, p = 0.043) were associated with HF rehospitalization. HF rehospitalization within 1 year was associated with nearly a 3-fold increased risk of mortality (HR 2.88, 95 % CI 2.00–4.15, p < 0.001). The HFC score was associated with a lower risk of all-cause mortality (HR 0.77, 95 % CI 0.62–0.95, p = 0.016) in the subgroup of patients with reduced ejection fraction.

Conclusions

Among adults with CHD hospitalized for HF, half of the patients were rehospitalized for HF. Rehospitalization within 1 year of the index HF hospitalization was associated with mortality. The use of GDMT for HF was associated with improved survival in patients with reduced ejection fraction.

成人先天性心脏病（ACHD）患者心衰（HF）再住院的危险因素以及指导药物治疗（GDMT）的效果尚不清楚。我们的目的是描述HF住院的结果，并评估GDMT治疗HF的临床益处。方法对2003 - 2023年梅奥诊所因心衰住院的ACHD患者进行回顾性队列研究。使用Cox比例风险模型来确定HF再住院和全因死亡率的预测因素，并评估死亡与GDMT之间的关系，通过心力衰竭协作评分来衡量。结果324例患者中，164例因心衰再次住院，149例死亡。10年累计再住院发生率为75.8% (95% CI 70.1% - 81.5%)， 10年死亡生存率为47.3% （95% CI 40.9% - 54.7%）。慢性肾脏疾病（HR 1.46, 95% CI 1.06-2.01, p = 0.021）和丰坦生理（HR 1.59, 95% CI 1.02-2.49, p = 0.043）与HF再住院相关。心力衰竭患者1年内再住院与死亡风险增加近3倍相关（HR 2.88, 95% CI 2.00-4.15, p < 0.001）。在射血分数降低的亚组中，HFC评分与较低的全因死亡风险相关（HR 0.77, 95% CI 0.62-0.95, p = 0.016）。结论在因心衰住院的成人冠心病患者中，有一半的患者再次因心衰住院。心力衰竭住院后1年内再次住院与死亡率相关。使用GDMT治疗心衰与射血分数降低患者的生存率提高相关。

{"title":"Prognostic implications of heart failure rehospitalization in adults with CHD & clinical benefits of medical therapy","authors":"Emili P. Rosado Rodriguez, Cynthia S. Crowson, Alexander C. Egbe","doi":"10.1016/j.ijcchd.2025.100640","DOIUrl":"10.1016/j.ijcchd.2025.100640","url":null,"abstract":"<div><h3>Background</h3><div>The risk factors for heart failure (HF) rehospitalization, and the effect of guideline directed medical therapy (GDMT) are poorly understood in adults with congenital heart disease (ACHD). We aimed to describe the outcomes of HF hospitalization and to assess the clinical benefits of GDMT for HF.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of ACHD hospitalized for HF at Mayo Clinic from 2003 to 2023. Cox proportional hazard models were used to determine the predictors of HF rehospitalization and all-cause mortality, and to assess the association between death and GDMT, as measured by the Heart Failure Collaborative score.</div></div><div><h3>Results</h3><div>Of the 324 patients, 164 were rehospitalized for HF and 149 died. The 10-year cumulative incidence of rehospitalization was 75.8 % (95 % CI 70.1 %–81.5 %), and the 10-year survival rate from mortality was 47.3 % (95 % CI 40.9 %–54.7 %). Chronic kidney disease (HR 1.46, 95 % CI 1.06–2.01, p = 0.021) and Fontan physiology (HR 1.59, 95 % CI 1.02–2.49, p = 0.043) were associated with HF rehospitalization. HF rehospitalization within 1 year was associated with nearly a 3-fold increased risk of mortality (HR 2.88, 95 % CI 2.00–4.15, p < 0.001). The HFC score was associated with a lower risk of all-cause mortality (HR 0.77, 95 % CI 0.62–0.95, p = 0.016) in the subgroup of patients with reduced ejection fraction.</div></div><div><h3>Conclusions</h3><div>Among adults with CHD hospitalized for HF, half of the patients were rehospitalized for HF. Rehospitalization within 1 year of the index HF hospitalization was associated with mortality. The use of GDMT for HF was associated with improved survival in patients with reduced ejection fraction.</div></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":"22 ","pages":"Article 100640"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlates of left ventricular hypertrophy in adults with coarctation of aorta and role in risk stratification 成人左室肥厚与主动脉缩窄的相关性及其在危险分层中的作用

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology. Congenital heart disease

Pub Date : 2025-11-22 DOI: 10.1016/j.ijcchd.2025.100642

Zeyad Kholeif, Ahmed E. Ali, Karim Ali, Marwan Ahmed, Ahmed Bahnasy, Meena Bai, Sara Aboelmaaty, Mohamed Ellabbad, Alexander C. Egbe

Background

Coarctation of aorta (COA) results in chronic left ventricular (LV) pressure overload and LV hypertrophy, which is associated with cardiovascular mortality. Therapies that decrease LV pressure overload result in regression of LV hypertrophy and improved survival. The goal of COA intervention is to relieve LV pressure overload, and the guidelines recommend the use of several COA severity indices as indications for intervention. These indices are Doppler mean gradient, systolic blood pressure (SBP), upper-to-lower-extremity SBP (ULE-SBP), aortic isthmus ratio, presence of collateral vessels, and exercise-induced hypertension (EIH). Although these indices are physiologically intuitive, it is unclear how many of these indices are required in order to recommend intervention, and the hierarchical importance of the different indices in patients that have some but not all the indices.

Methods

In this cross-sectional study, multivariate linear regression analysis was used to assess the correlation between LV mass index (LVMI) and indices of COA severity.

Results

Of the COA indices analyzed in 811 adult with repaired COA patients, aortic isthmus ratio had the strongest correlation with LVMI (β coefficients ±standard error −31.6 ± 13.8, p < 0.001), as compared to Doppler peak gradient (0.79 ± 0.22, p = 0.002) and SBP (0.53 ± 0.21, p = 0.03).

Conclusion

Aortic isthmus ratio had the strongest correlation with LVMI, which is a reflection of chronic LV pressure overload. An aortic isthmus ratio ≤0.7 was the optimal cut-off point to detect LV hypertrophy with good sensitivity and specificity. These results can potentially improve and simplify patient selection for COA intervention.

背景：主动脉缩窄（COA）导致慢性左室（LV）压力过载和左室肥厚，这与心血管疾病死亡率相关。减少左室压力过载的治疗可导致左室肥大的消退和生存率的提高。COA干预的目标是缓解左室压力过载，指南建议使用几个COA严重程度指标作为干预的指征。这些指标是多普勒平均梯度、收缩压（SBP）、上下肢收缩压（ULE-SBP）、主动脉峡比、侧支血管的存在和运动性高血压（EIH）。虽然这些指标在生理上是直观的，但目前尚不清楚需要多少这些指标才能推荐干预措施，以及不同指标在具有某些但不是全部指标的患者中的等级重要性。方法采用多变量线性回归分析，评价左室质量指数（LVMI）与COA严重程度指标的相关性。结果811例成人COA修复患者的COA指标中，主动脉峡部比值与LVMI （β系数±标准误差- 31.6±13.8,p < 0.001）、多普勒峰梯度（0.79±0.22,p = 0.002）和收缩压（0.53±0.21,p = 0.03）的相关性最强。结论主动脉峡比与LVMI相关性最强，是慢性左室压过负荷的反映。主动脉峡部比值≤0.7是检测左室肥厚的最佳分界点，具有良好的敏感性和特异性。这些结果可以潜在地改善和简化COA干预的患者选择。

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引用次数: 0

Congenital heart disease in men of reproductive age: Nationwide cohort studies of prevalence, male fertility, and birth outcomes in offspring 育龄男性先天性心脏病：患病率、男性生育能力和后代出生结局的全国队列研究

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

International journal of cardiology. Congenital heart disease

Pub Date : 2025-11-06 DOI: 10.1016/j.ijcchd.2025.100637

Marit Sandberg , Nina Øyen , Tatiana Fomina , Ferenc Macsali , Gottfried Greve , Elisabeth Leirgul

Background

The potential for men with congenital heart disease (CHD) to father children and the impact of paternal CHD on offspring birth outcomes are not well understood.

Methods

Using Norwegian nationwide registries from 1994 to 2014, we identified two study populations: 1 829 877 men aged 18–50 years and 1 207 410 newborns. First, we reported the time trends of CHD in men and paternal CHD in newborns. Second, we compared the rate of becoming fathers in men with and without CHD. Third, we compared birth outcomes in offspring with and without paternal CHD.

Results

Between 1994 and 2014, the prevalence of CHD in men of reproductive age increased from 22.7 to 32.2 per 10 000, while the prevalence of paternal CHD in newborns increased from 21.6 to 26.9 per 10 000. Men with mild CHD had a similar rate of becoming fathers compared to men without CHD (rate ratio 0.97, 95 % confidence interval 0.90–1.05), but men with moderate/severe CHD had a lower rate (rate ratio 0.78, 95 % confidence interval 0.70–87). Newborns with paternal CHD had no increased risk of preterm birth or being small for gestational age, compared to newborns without paternal CHD.

Conclusion

The prevalence of CHD in men and paternal CHD in newborns was increasing. Moderate/severe CHD in men was associated with a lower rate of becoming fathers compared to the general male population. Paternal CHD was not associated with an increased risk of newborns being preterm or small for gestational age.

研究背景先天性心脏病（CHD）男性是否有可能成为孩子的父亲，以及父亲的CHD对后代出生结局的影响尚不清楚。方法利用1994 - 2014年挪威全国登记资料，确定了两个研究人群：18-50岁男性1 829 877人，新生儿1 207 410人。首先，我们报道了男性冠心病和新生儿父亲冠心病的时间趋势。其次，我们比较了有和没有冠心病的男性成为父亲的比率。第三，我们比较了有和没有父亲冠心病的后代的出生结果。结果1994 - 2014年育龄男性冠心病患病率从22.7 / 1万上升到32.2 / 1万，新生儿父亲冠心病患病率从21.6 / 1万上升到26.9 / 1万。与非冠心病男性相比，轻度冠心病男性成为父亲的比率相似（比率比0.97,95%可信区间0.90-1.05），但中度/重度冠心病男性的比率较低（比率比0.78,95%可信区间0.70-87）。与没有父亲冠心病的新生儿相比，父亲冠心病的新生儿早产或胎龄小的风险没有增加。结论男性冠心病患病率和新生儿父系冠心病患病率呈上升趋势。与一般男性人群相比，中度/重度冠心病男性成为父亲的几率较低。父亲患冠心病与新生儿早产或小于胎龄的风险增加无关。

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引用次数: 0

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