Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries

IF 0.8 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS International journal of cardiology. Congenital heart disease Pub Date : 2024-10-23 DOI:10.1016/j.ijcchd.2024.100550
{"title":"Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries","authors":"","doi":"10.1016/j.ijcchd.2024.100550","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and aims</h3><div>The objective of this study was to assess the associations of birth weight with cardiac structure and function in adults with dextro-transposition of the great arteries (D-TGA) who underwent the arterial switch operation (ASO).</div></div><div><h3>Methods and results</h3><div>Thirty-nine ASO patients (age 24.4 ± 3.3 years) were included during routine clinical follow-up from July 2019 to December 2021. All patients underwent cardiopulmonary exercise testing and cardiac magnetic resonance imaging at rest and during exercise. Early-life characteristics, including birth weight, were extracted from electronic medical health records. Linear regression analysis showed that lower birth weight was associated with smaller left ventricular (LV) and right ventricular (RV) end-diastolic volume index (LV: −14.5 mL/m<sup>2</sup> [95 % confidence interval, CI: −26.5 to −2.5] per 1-kg decrease in birth weight, <em>p</em> = 0.04; RV: −11.2 mL/m<sup>2</sup> [-20.7 to −1.7] per 1-kg decrease in birth weight, <em>p</em> = 0.03). Lower birth weight was associated with greater LV and RV ejection fraction at rest (LV: +8.5 % [+4.4 to +12.5] per 1-kg decrease in birth weight, <em>p</em> &lt; 0.001); RV: +8.1 % [+2.8 to +13.4] per 1-kg decrease in birth weight, <em>p</em> = 0.005). Furthermore, lower birth weight was associated with an attenuated increase in LV stroke volume index from rest to peak exercise (−5.2 mL/m<sup>2</sup> [-9.3 to −1.2] per 1-kg decrease in birth weight, <em>p</em> = 0.02).</div></div><div><h3>Conclusions</h3><div>Birth weight may be a novel risk factor for adverse cardiac remodeling in adult ASO patients. Further research is needed to delineate the mechanisms underlying the associations between birth weight and cardiac remodeling ASO patients as well as the broader adult CHD population.</div></div>","PeriodicalId":73429,"journal":{"name":"International journal of cardiology. Congenital heart disease","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of cardiology. Congenital heart disease","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666668524000594","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

Abstract

Background and aims

The objective of this study was to assess the associations of birth weight with cardiac structure and function in adults with dextro-transposition of the great arteries (D-TGA) who underwent the arterial switch operation (ASO).

Methods and results

Thirty-nine ASO patients (age 24.4 ± 3.3 years) were included during routine clinical follow-up from July 2019 to December 2021. All patients underwent cardiopulmonary exercise testing and cardiac magnetic resonance imaging at rest and during exercise. Early-life characteristics, including birth weight, were extracted from electronic medical health records. Linear regression analysis showed that lower birth weight was associated with smaller left ventricular (LV) and right ventricular (RV) end-diastolic volume index (LV: −14.5 mL/m2 [95 % confidence interval, CI: −26.5 to −2.5] per 1-kg decrease in birth weight, p = 0.04; RV: −11.2 mL/m2 [-20.7 to −1.7] per 1-kg decrease in birth weight, p = 0.03). Lower birth weight was associated with greater LV and RV ejection fraction at rest (LV: +8.5 % [+4.4 to +12.5] per 1-kg decrease in birth weight, p < 0.001); RV: +8.1 % [+2.8 to +13.4] per 1-kg decrease in birth weight, p = 0.005). Furthermore, lower birth weight was associated with an attenuated increase in LV stroke volume index from rest to peak exercise (−5.2 mL/m2 [-9.3 to −1.2] per 1-kg decrease in birth weight, p = 0.02).

Conclusions

Birth weight may be a novel risk factor for adverse cardiac remodeling in adult ASO patients. Further research is needed to delineate the mechanisms underlying the associations between birth weight and cardiac remodeling ASO patients as well as the broader adult CHD population.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
低出生体重与大动脉转位术后成人心脏结构和功能的关系
背景和目的本研究旨在评估接受动脉转换手术(ASO)的成人大动脉右侧横位(D-TGA)患者的出生体重与心脏结构和功能的关系。所有患者均接受了静息和运动时的心肺运动测试和心脏磁共振成像。从电子医疗健康记录中提取了包括出生体重在内的早期生活特征。线性回归分析表明,较低的出生体重与较小的左心室(LV)和右心室(RV)舒张末期容积指数(LV:出生体重每下降 1 公斤,左心室和右心室舒张末期容积指数为-14.5 mL/m2 [95 % 置信区间,CI:-26.5 至-2.5],p = 0.04;右心室舒张末期容积指数为-11.2 mL/m2 [95 % 置信区间,CI:-11.2 至-2.5],p = 0.04:-出生体重每下降 1 公斤,RV:-11.2 mL/m2 [-20.7 至 -1.7],p = 0.03)。出生体重每下降 1 公斤,左心室:+8.1 % [+2.8 至 +13.4],p = 0.005)。此外,出生时体重较低与左心室搏出量指数从静息到运动峰值的增加减弱有关(出生时体重每减少 1 公斤,左心室搏出量指数增加-5.2 mL/m2 [-9.3 至 -1.2] ,p = 0.02)。出生体重可能是导致成年 ASO 患者心脏重塑不良的新风险因素,需要进一步研究来阐明出生体重与 ASO 患者以及更广泛的成年心脏病人群心脏重塑之间的关联机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
International journal of cardiology. Congenital heart disease
International journal of cardiology. Congenital heart disease Cardiology and Cardiovascular Medicine
自引率
0.00%
发文量
0
审稿时长
83 days
期刊最新文献
Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries Segmental MRI pituitary and hypothalamus volumes post Fontan: An analysis of the Australian and New Zealand Fontan registry Infective endocarditis: Awareness, knowledge gaps and behaviours amongst adults with congenital heart disease Comparative analysis of diagnostic accuracy in adult congenital heart disease: A study of three physician groups and ChatGPT Oxygen uptake efficiency slope at anaerobic threshold can predict peak VO2 in adult congenital heart disease
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1