Application of multispectral optoacoustic tomography for lower limb musculoskeletal sports injuries in adults

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL Photoacoustics Pub Date : 2024-10-09 DOI:10.1016/j.pacs.2024.100656

Rene B. Svensson , Anne-Sofie Agergaard , Thomas Sardella , Charlène Reichl , Mikkel H. Hjortshoej , Monika L. Bayer , Rikke Hoeffner , Christian Couppé , Michael Kjaer , S. Peter Magnusson

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Abstract

Compositional changes in relation to musculoskeletal injuries are difficult to measure non-invasively. This study aims to use non-invasive label-free imaging with Multispectral Optoacoustic Tomography (MSOT) to evaluate compositional changes with injury. Five different patient groups were examined, covering diagnoses of Achilles or patellar tendinopathy, Achilles tendon rupture and gastrocnemius muscle strain injury. Injured and contralateral limbs were imaged using a commercial MSOT device. Hemoglobin, collagen, and lipid contents were estimated. Some patients were examined before and after exercise. Hemoglobin measures had high reproducibility and displayed systematic changes in response to exercise. The content and exercise response of hemoglobin was equal on both limbs. In contrast, collagen and lipid measures were inconsistent and did not display the expected distribution. In conclusion, MSOT is applicable to imaging of hemoglobin in musculoskeletal injuries, providing complimentary information to conventional ultrasound, but applicability to other components like collagen and lipids could not be shown.

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多谱段光声断层扫描在成人下肢肌肉骨骼运动损伤中的应用

与肌肉骨骼损伤有关的成分变化很难进行无创测量。本研究旨在利用多谱勒光声断层扫描（MSOT）的无创无标记成像技术来评估损伤时的成分变化。研究对象包括五组不同的患者，诊断为跟腱或髌腱病、跟腱断裂和腓肠肌劳损。使用商用 MSOT 设备对受伤肢体和对侧肢体进行成像。对血红蛋白、胶原蛋白和脂质含量进行估算。一些患者在运动前后都接受了检查。血红蛋白的测量结果具有很高的重现性，并显示出对运动反应的系统性变化。双侧肢体的血红蛋白含量和运动反应相同。相比之下，胶原蛋白和脂质的测量结果不一致，也没有显示出预期的分布。总之，MSOT 适用于肌肉骨骼损伤中血红蛋白的成像，可为传统超声波提供补充信息，但无法显示其对胶原蛋白和脂质等其他成分的适用性。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.