Engineered Multifunctional BioHJzyme via Tuning D-Band Center for Postoperative Infected Wound Regeneration of Tumor Resection

Abstract

The catalytic therapy for abundant •OH, ¹O₂, and •O₂⁻ provides an efficient tactic and methodology for rapid tumor/bacteria killing, whereas the limitation is focused on the catalytic efficiency owing to the in-built energy band of catalytic materials. Thus, d-band center tuning BioHJzyme is devised, which is composed of zinc tellurate/manganese dioxide anchored by glucose oxidase (GOx) with anti-tumor and anti-bacteria properties for postoperative infected wound regeneration of tumor. The GOx depletes glucose to produce H₂O₂, intercepting the glucose metabolism. The D-BioHJzyme can catalyze the produced H₂O₂ to highly lethal •OH with POD-mimetic activity owing to the tunned d-band center strategy decreasing the adsorption energy of the intermediate in the catalytical process, while the oxygen originated from H₂O₂ and Mn²⁺ can be catalyzed into ¹O₂. The GPx-mimetic activity of it can impair the antioxidant system of tumor. In vivo studies show that the BioHJzyme exhibits robust abilities against bacteria and tumors by •OH/¹O₂ production and promotes the apoptosis owing the Te. Besides, the BioHJzyme can accelerate cutaneous regeneration by M1/M2 regulation and the angiogenesis/collagen deposition. This work enlightens a powerful platform for the remedy of postoperative infected wound regeneration of tumor resection using an engineered BioHJzyme.