{"title":"A Comprehensive Review of Self-Nanoemulsifying Systems in the Delivery of Herbal Drugs.","authors":"Manoj Harde, Rashmi Mallya","doi":"10.2174/0122117385325207240910073653","DOIUrl":null,"url":null,"abstract":"<p><p>Self-nanoemulsifying drug delivery systems (SNEDDS) are an isotropic mixture of oils, co-surfactants, and surfactants and can form fine O/W Nanoemulsions in aqueous media. These components are advantageous in terms of improved solubility and bioavailability. Limited permeability, solubility, and bioavailability remain a significant challenge in developing herbal drugs. This review explores the potential of self-nanoemulsifying drug delivery systems (SNEDDS) as a promising strategy to overcome this problem. The SNEDDS is considered a novel technique for the delivery of low water-soluble drugs. It can bypass the first-pass metabolism, resulting in steady and sustained drug levels in the systemic circulation. The present article provides a comprehensive overview of the SNEDDS formulation of herbal drugs. It includes their composition, characterization, in vitro and in vivo studies conducted in various disease conditions, and pharmacokinetic studies.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutical nanotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0122117385325207240910073653","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
Self-nanoemulsifying drug delivery systems (SNEDDS) are an isotropic mixture of oils, co-surfactants, and surfactants and can form fine O/W Nanoemulsions in aqueous media. These components are advantageous in terms of improved solubility and bioavailability. Limited permeability, solubility, and bioavailability remain a significant challenge in developing herbal drugs. This review explores the potential of self-nanoemulsifying drug delivery systems (SNEDDS) as a promising strategy to overcome this problem. The SNEDDS is considered a novel technique for the delivery of low water-soluble drugs. It can bypass the first-pass metabolism, resulting in steady and sustained drug levels in the systemic circulation. The present article provides a comprehensive overview of the SNEDDS formulation of herbal drugs. It includes their composition, characterization, in vitro and in vivo studies conducted in various disease conditions, and pharmacokinetic studies.
期刊介绍：
Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.
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