Analytical and drug delivery strategies for short peptides: From manufacturing to market

IF 2.6 4区 生物学 Q2 BIOCHEMICAL RESEARCH METHODS Analytical biochemistry Pub Date : 2024-10-24 DOI:10.1016/j.ab.2024.115699
Ashwini Chawathe , Vishal Ahire , Kshitiz Luthra , Bhumika Patil , Kalpna Garkhal , Nitish Sharma
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Abstract

In recent times, biopharmaceuticals have gained attention because of their tremendous potential to benefit millions of patients globally by treating widespread diseases such as cancer, diabetes and many rare diseases. Short peptides (SP), also termed as oligopeptides, are one such class of biopharmaceuticals, that are majorly involved in efficient functioning of biological systems. Peptide chains that are 2–20 amino acids long are considered as oligopeptides by researchers and are some of the functionally vital compounds with widespread applications including self-assembly material for drug delivery, targeting ligands for precise/specific targeting and other biological uses. Using functionalised biomacromolecules such as short chained peptides, helps in improving pharmacokinetic properties and biodistribution profile of the drug. Apart from this, functionalised SP are being employed as cell penetrating peptides and prodrug to specifically and selectively target tumor sites. In order to minimize any unwanted interaction and adverse effects, the stability and safety of SP should be ensured throughout its development from manufacturing to market. Formulation development and characterization strategies of these potential molecules are described in the following review along with various applications and details of marketed formulations.

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短肽的分析和给药策略:从制造到上市。
近来,生物制药因其治疗癌症、糖尿病和许多罕见疾病等广泛疾病的巨大潜力而备受全球数百万患者的关注。短肽(SP),又称寡肽,就是这样一类生物制药,主要参与生物系统的有效运作。研究人员将长度为 2-20 个氨基酸的肽链视为寡肽,它们是一些具有重要功能的化合物,应用广泛,包括用于药物输送的自组装材料、用于精确/特异性靶向的靶向配体以及其他生物用途。使用短链肽等功能化生物大分子有助于改善药物的药代动力学特性和生物分布特征。除此之外,功能化 SP 还可用作细胞穿透肽和原药,以特异性和选择性地靶向肿瘤部位。为了最大限度地减少任何不必要的相互作用和不良反应,在从生产到上市的整个研发过程中,都应确保 SP 的稳定性和安全性。下文将介绍这些潜在分子的制剂开发和表征策略,以及各种应用和上市制剂的详细情况。
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来源期刊
Analytical biochemistry
Analytical biochemistry 生物-分析化学
CiteScore
5.70
自引率
0.00%
发文量
283
审稿时长
44 days
期刊介绍: The journal''s title Analytical Biochemistry: Methods in the Biological Sciences declares its broad scope: methods for the basic biological sciences that include biochemistry, molecular genetics, cell biology, proteomics, immunology, bioinformatics and wherever the frontiers of research take the field. The emphasis is on methods from the strictly analytical to the more preparative that would include novel approaches to protein purification as well as improvements in cell and organ culture. The actual techniques are equally inclusive ranging from aptamers to zymology. The journal has been particularly active in: -Analytical techniques for biological molecules- Aptamer selection and utilization- Biosensors- Chromatography- Cloning, sequencing and mutagenesis- Electrochemical methods- Electrophoresis- Enzyme characterization methods- Immunological approaches- Mass spectrometry of proteins and nucleic acids- Metabolomics- Nano level techniques- Optical spectroscopy in all its forms. The journal is reluctant to include most drug and strictly clinical studies as there are more suitable publication platforms for these types of papers.
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