Prevalence of poststroke anxiety and its associations with global cognitive impairment: An individual participant data analysis.

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY Journal of affective disorders Pub Date : 2025-01-15 Epub Date: 2024-10-22 DOI:10.1016/j.jad.2024.10.099

Florine Ruthmann, Jessica W Lo, Anne-Marie Mendyk-Bordet, Etienne Allart, Sebastian Köhler, Aleksandra Klimkowicz-Mrowiec, Julie Staals, Perminder S Sachdev, Régis Bordet, Thibaut Dondaine

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Abstract

Background and purpose: Anxiety is frequent after stroke; however, little is known about its determinants. This study aims to assess the prevalence and correlates of post stroke anxiety (PSA) within 3-6 months following ischemic stroke.

Methods: Three cohort studies from the STROKOG consortium were involved. Demographic and clinical data were standardized. PSA and PSD were assessed using inventories. The criteria for post-stroke cognitive impairment (PSCI) were at least one cognitive domain impaired if applicable, or a Montreal Cognitive Assessment (MoCA) score. Descriptive analyses were conducted to ascertain the prevalence of anxiety. Comparisons between anxious and non-anxious patients in the total sample were made using χ² and t-tests. A two-step individual participant data (IPD) meta-analysis was employed to identify factors associated with PSA.

Results: 584 patients were included. The total prevalence of PSA was 35 % (95%CI = [31.23;38.97]) and ranged from 27 % to 45 % across cohorts. In the total sample, there was a higher proportion of females in the anxiety group than the non-anxiety group (χ² = 19.62; p < 0.001). Anxious patients had lower education, (χ² = 6.59; p = 0.03), higher stroke severity (t = 2.77; p = 0.002), and higher rates of PSD (χ² = 118.09; p < 0.001), and PSCI (χ² = 23.81, p < 0.001). The analysis demonstrates that the odds of presenting with PSA is larger in patients with PSCI (OR = 1.84, 95%CI = [1.14; 2.91]).

Conclusions: Anxiety is frequent after stroke, especially in females, and is associated with depression and cognitive impairment.

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脑卒中后焦虑的普遍性及其与整体认知障碍的关系：个体参与者数据分析

背景和目的：中风后经常出现焦虑；然而，人们对其决定因素知之甚少。本研究旨在评估缺血性中风后 3-6 个月内中风后焦虑症（PSA）的患病率及其相关因素：方法：STROKOG 联合体的三项队列研究参与其中。方法：STROKOG 联合体的三项队列研究参与其中。PSA 和 PSD 采用量表进行评估。卒中后认知障碍（PSCI）的标准是至少有一个认知领域受损（如适用），或蒙特利尔认知评估（MoCA）得分。为了确定焦虑症的患病率，我们进行了描述性分析。使用 χ2 和 t 检验对总样本中的焦虑患者和非焦虑患者进行比较。采用两步个体参与者数据（IPD）荟萃分析来确定与 PSA 相关的因素：结果：共纳入 584 名患者。PSA的总患病率为35%（95%CI = [31.23;38.97]），各组群的患病率从27%到45%不等。在所有样本中，焦虑组的女性比例高于非焦虑组（χ2 = 19.62; p 2 = 6.59; p = 0.03），中风严重程度更高（t = 2.77; p = 0.002），PSD 的发生率更高（χ2 = 118.09; p 2 = 23.81, p 结论：焦虑是中风后的常见症状：中风后焦虑是常见病，尤其是女性，并与抑郁和认知障碍相关。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.