Depressive symptoms are linked to age-specific neuroanatomical and cognitive variations.

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Journal of affective disorders Pub Date : 2025-01-15 Epub Date: 2024-10-22 DOI:10.1016/j.jad.2024.10.077
Eyal Bergmann, Daniel Harlev, Noham Wolpe
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Abstract

Depression is a heterogeneous disorder, both in terms of patient symptomatology and in patient sociodemographic factors. Here, we examine the contribution of age to this heterogeneity, by characterizing the associations of depressive symptoms with cognitive performance and brain structure across the lifespan. We analyzed data from the Cambridge Centre for Aging Neuroscience (Cam-CAN) cohort (N = 2591, age 18-99). A subset of this cohort (N = 647) underwent structural MRI. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale. Cognitive assessments were performed using The Addenbrooke's Cognitive Examination Revised. Generalized linear models were employed to examine the relationship between depressive symptoms and cognitive performance. Statistical parametric mapping explored age-dependent associations between depressive symptoms and grey matter volume. Cognitive performance was associated with a significant age by depression by cognitive domain interaction, indicating that older individuals with more depressive symptoms had a lower cognitive performance, particularly in the fluency domain. Structural MRI revealed preferential depression-related reduction in grey matter volume in the left and right hippocampi in older adults. By contrast, in younger adults, depressive symptoms were more strongly associated with grey matter volume reduction in the left superior frontal gyrus and left middle frontal gyrus. Collectively, these findings indicate that the associations of depression with cognitive performance and brain structure are age-dependent, suggesting that the pathophysiological mechanisms underlying depression may differ between young and older adults. Recognizing these differences will support the development of better diagnostic tools and therapeutic interventions for depression across the lifespan.

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抑郁症状与特定年龄的神经解剖和认知变化有关。
无论是从患者的症状还是从患者的社会人口因素来看,抑郁症都是一种异质性疾病。在此,我们通过分析抑郁症状与整个生命周期的认知能力和大脑结构之间的关系,研究了年龄对这种异质性的影响。我们分析了剑桥老年神经科学中心(Cam-CAN)队列(N = 2591,18-99 岁)的数据。该队列中的一个子集(N = 647)接受了结构性核磁共振成像检查。抑郁症状采用医院焦虑抑郁量表(Hospital Anxiety and Depression Scale)进行测量。认知评估采用《阿登布鲁认知检查修订版》进行。采用广义线性模型来研究抑郁症状与认知能力之间的关系。统计参数映射探讨了抑郁症状与灰质体积之间的年龄相关性。认知表现与年龄、抑郁症和认知领域之间存在显著的交互作用,这表明抑郁症状较多的老年人认知表现较差,尤其是在流畅性领域。结构性核磁共振成像显示,与抑郁症相关的是老年人左右海马灰质体积的减少。相比之下,在年轻人中,抑郁症状与左侧额上回和左侧额中回灰质体积减少的关系更为密切。总之,这些研究结果表明,抑郁症与认知能力和大脑结构的关系与年龄有关,这表明年轻人和老年人抑郁症的病理生理机制可能有所不同。认识到这些差异将有助于开发更好的诊断工具和治疗干预措施,以治疗整个生命周期的抑郁症。
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来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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