Effects of ensemble-forecasted key environmental factors on the distribution, active constituents, and transcription regulation in Ligusticum chuanxiong Hort.

IF 3.3 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of the Science of Food and Agriculture Pub Date : 2024-10-25 DOI:10.1002/jsfa.13970

Tingting Zhang, Lili Zhou, Ying Han, Wanqing Feng, Chao Chen, Jiawei Wen, Cheng Peng, Yang He

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Abstract

Background: Ligusticum chuanxiong Hort., with over 2000 years of medicinal use and cultivation history, is extensively used in clinical settings for treating heart disease, headache, dysmenorrhea, and amenorrhea. Constructing the geographic distribution pattern of L. chuanxiong and identifying the environmental factors limiting its range, as well as clarifying the effects of key environmental factors on the content of major active constituents and transcription regulation, could provide a scientific foundation for the conservation and effective management of this valuable medicinal resource.

Results: The results reveal that the predominant environmental factors influencing the distribution were the minimum temperature of the coldest month (Bio6) and solar radiation (Srad), with cumulative account for 87.46% of the importance. Correlation analysis further reveals significant negative correlations between Bio6 and the content of major active constituents in L. chuanxiong, with Srad exhibiting a negative correlation with these constituents. The gene differential expression analysis indicated that the expression levels of some genes associated with growth and active constituent biosynthesis pathways, such as RPT2_13888, UVR8_16871, CLPB3_3155, and 4CLL5_116, varied significantly among locations influenced by differing key environmental factors. Consequently, alterations in the environment were found to influence the gene expression levels within these pathways, resulting in variations in the content of active constituents.

Conclusions: These findings contribute to an enhanced understanding of how environmental factors impact the distribution and quality of medicinal plants and offer a theoretical reference for the introduction, cultivation, quality improvement, resource utilization and management of L. chuanxiong. © 2024 Society of Chemical Industry.

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集合预测的关键环境因素对川芎分布、活性成分和转录调控的影响

背景：川芎具有2000多年的药用和栽培历史，在临床上被广泛用于治疗心脏病、头痛、痛经和闭经。构建川芎的地理分布格局，确定限制其分布范围的环境因素，并阐明主要环境因素对其主要活性成分含量和转录调控的影响，可为保护和有效管理这一宝贵的药用资源提供科学依据：结果表明，影响分布的主要环境因素是最冷月的最低气温（Bio6）和太阳辐射（Srad），两者的累积影响占 87.46%。相关性分析进一步表明，Bio6 与川芎中主要活性成分的含量呈显著负相关，Srad 与这些成分也呈负相关。基因差异表达分析表明，一些与生长和活性成分生物合成途径相关的基因，如 RPT2_13888、UVR8_16871、CLPB3_3155 和 4CLL5_116 的表达水平受不同关键环境因素的影响而在不同地点存在显著差异。因此，环境的改变会影响这些通路的基因表达水平，从而导致活性成分含量的变化：这些发现有助于加深对环境因素如何影响药用植物分布和质量的理解，并为川芎的引种、栽培、质量改进、资源利用和管理提供理论参考。© 2024 化学工业学会。

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.