Fluorescent nanoparticles from roast duck induce cell damage and physiological dysfunction in Caenorhabditis elegans

IF 3.5 2区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of the Science of Food and Agriculture Pub Date : 2024-11-28 DOI:10.1002/jsfa.14052

Guoxin Cui, Shuang Cong, Mingqian Tan

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Abstract

Background

The safety of fluorescent nanoparticles (FNPs) that enter the human body through food consumption is uncertain. In this study, the biocompatibility of FNPs derived from roast duck was investigated using pheochromocytoma (PC12) cells and Caenorhabditis elegans.

Results

Fluorescent nanoparticles, at concentrations of 1 and 4 mg mL⁻¹, caused an increase in early apoptosis, altered the cell cycle, elevated reactive oxygen species levels, and decreased mitochondrial membrane potential in PC12 cells. Both acute and prolonged exposure to the FNPs enabled them to permeate C. elegans via its food source, accumulating predominantly in the intestine. At concentrations ranging between 0 and 15 mg mL⁻¹, FNPs did not induce mortality in C. elegans but they did affect its growth, reproductive ability, and motor behavior.

Conclusion

This study advances the understanding of FNP safety significantly, facilitates risk assessment for foods containing FNPs, and provides valuable guidance to ensure food safety. © 2024 Society of Chemical Industry.

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烤鸭中的荧光纳米粒子会诱发草履虫细胞损伤和生理功能紊乱。

背景：通过食用进入人体的荧光纳米粒子（FNPs）的安全性尚不确定。本研究利用嗜铬细胞瘤（PC12）细胞和秀丽隐杆线虫研究了从烤鸭中提取的 FNPs 的生物相容性：结果：浓度为 1 毫克毫升/升和 4 毫克毫升/升的荧光纳米粒子会导致 PC12 细胞早期凋亡增加、细胞周期改变、活性氧水平升高和线粒体膜电位降低。无论是急性接触还是长期接触 FNPs，它们都能通过食物源渗透到秀丽隐杆线虫体内，并主要在肠道中积累。在 0 至 15 毫克毫升/升的浓度范围内，FNPs 不会导致秀丽隐杆线虫死亡，但会影响其生长、繁殖能力和运动行为：这项研究大大加深了人们对 FNP 安全性的认识，有助于对含有 FNP 的食品进行风险评估，并为确保食品安全提供了宝贵的指导。© 2024 化学工业协会。

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来源期刊

Journal of the Science of Food and Agriculture 工程技术-农业综合

CiteScore

8.10

自引率

4.90%

发文量

634

审稿时长

3.1 months

期刊介绍： The Journal of the Science of Food and Agriculture publishes peer-reviewed original research, reviews, mini-reviews, perspectives and spotlights in these areas, with particular emphasis on interdisciplinary studies at the agriculture/ food interface. Published for SCI by John Wiley & Sons Ltd. SCI (Society of Chemical Industry) is a unique international forum where science meets business on independent, impartial ground. Anyone can join and current Members include consumers, business people, environmentalists, industrialists, farmers, and researchers. The Society offers a chance to share information between sectors as diverse as food and agriculture, pharmaceuticals, biotechnology, materials, chemicals, environmental science and safety. As well as organising educational events, SCI awards a number of prestigious honours and scholarships each year, publishes peer-reviewed journals, and provides Members with news from their sectors in the respected magazine, Chemistry & Industry . Originally established in London in 1881 and in New York in 1894, SCI is a registered charity with Members in over 70 countries.