Design and Implementation of a Computer-Controlled Hybrid Oscillatory Ventilator.

IF 0.8 4区 医学 Q4 ENGINEERING, BIOMEDICAL Journal of Medical Devices-Transactions of the Asme Pub Date : 2025-03-01 Epub Date: 2024-10-22 DOI:10.1115/1.4066679
Andrea F Cruz, Jacob Herrmann, Bakir Hajdarevic, Monica L Hawley, Donald Fox, Jason H T Bates, David W Kaczka
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Abstract

During mechanical ventilation, lung function and gas exchange in structurally heterogeneous lungs may be improved when volume oscillations at the airway opening are applied at multiple frequencies simultaneously, a technique referred to as multifrequency oscillatory ventilation (MFOV). This is in contrast to conventional high-frequency oscillatory ventilation (HFOV), for which oscillatory volumes are applied at a single frequency. In the present study, as a means of fully realizing the potential of MFOV, we designed and tested a computer-controlled hybrid oscillatory ventilator capable of generating the flows, tidal volumes, and airway pressures required for MFOV, HFOV, conventional mechanical ventilation (CMV), as well as oscillometric measurements of respiratory impedance. The device employs an iterative spectral feedback controller to generate a wide range of oscillatory waveforms. The performance of the device meets that of commercial mechanical ventilators in volume-controlled mode. Oscillatory modes of ventilation also meet design specifications in a mechanical test lung, over frequencies from 4 to 20 Hz and mean airway pressure from 5 to 30 cmH2O. In proof-of-concept experiments, the oscillatory ventilator maintained adequate gas exchange in a porcine model of acute lung injury, using combinations of conventional and oscillatory ventilation modalities. In summary, our novel device is capable of generating a wide range of conventional and oscillatory ventilation waveforms with potential to enhance gas exchange, while simultaneously providing less injurious ventilation.

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计算机控制的混合振荡通风机的设计与实施。
在机械通气过程中,如果在气道开口处同时以多种频率进行容积振荡,可改善结构异质肺的肺功能和气体交换,这种技术被称为多频振荡通气(MFOV)。这与传统的高频振荡通气(HFOV)形成了鲜明对比,后者只在单一频率下进行体积振荡。在本研究中,为了充分发挥 MFOV 的潜力,我们设计并测试了一种计算机控制的混合振荡通气设备,该设备能够产生 MFOV、HFOV 和传统机械通气(CMV)所需的流量、潮气量和气道压力,并能对呼吸阻抗进行振荡测量。该设备采用迭代频谱反馈控制器,可产生多种振荡波形。在容量控制模式下,该设备的性能达到了商用机械呼吸机的水平。振荡通气模式也符合机械测试肺的设计规范,频率范围为 4 到 20 Hz,平均气道压力范围为 5 到 30 cmH2O。在概念验证实验中,振荡通风机在猪急性肺损伤模型中使用传统通气模式和振荡通气模式组合维持了充分的气体交换。总之,我们的新型设备能够产生多种常规和振荡通气波形,具有增强气体交换的潜力,同时提供损伤较小的通气。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.80
自引率
11.10%
发文量
56
审稿时长
6-12 weeks
期刊介绍: The Journal of Medical Devices presents papers on medical devices that improve diagnostic, interventional and therapeutic treatments focusing on applied research and the development of new medical devices or instrumentation. It provides special coverage of novel devices that allow new surgical strategies, new methods of drug delivery, or possible reductions in the complexity, cost, or adverse results of health care. The Design Innovation category features papers focusing on novel devices, including papers with limited clinical or engineering results. The Medical Device News section provides coverage of advances, trends, and events.
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