Gut microbiota in women with polycystic ovary syndrome: an individual based analysis of publicly available data.

IF 9.6 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL EClinicalMedicine Pub Date : 2024-10-18 eCollection Date: 2024-11-01 DOI:10.1016/j.eclinm.2024.102884
Yanan Yang, Jiale Cheng, Chongyuan Liu, Xiaopo Zhang, Ning Ma, Zhi Zhou, Weiying Lu, Chongming Wu
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Abstract

Background: Polycystic ovary syndrome (PCOS) represents a prevalent endocrine disorder affecting numerous females worldwide. Dysbiosis of gut microbiota has been linked to the occurrence of PCOS; however, research into the characteristics of gut microbiota in PCOS patients, especially those from different regions and with different testosterone level, remains limited. Additionally, it is still unclear whether gut microbiota helps to distinguish different PCOS subtypes.

Methods: We searched four electronic databases (PubMed, Web of Science, Cochrane Library, and ClinicalTrials.gov) from Jan 1, 2010 to May 1, 2024. This combined analysis included studies providing the raw data of gut microbiota in PCOS patients. We reanalyzed the characteristics of gut microbiota in PCOS patients from different regions and with different testosterone level.

Findings: Fourteen publications satisfying the inclusion criteria were included in the combined analysis. Based on data from 948 individuals, we found alpha-diversity was not significantly different between PCOS and healthy control (HC) groups. However, gut microbiota composition was distinct in PCOS patients compared with healthy individuals. Specifically, Fusobacterium, Ruminococcus_gnavus_group, and Escherichia-Shigella increased, while Dysosmobacter, Schaedlerella, Merdimonas, Clostridiisalibacter, Flintibacter et al. decreased in PCOS women. Regionally, Alistipes was enriched in primarily European patients, while Blautia and Roseburia were more abundant in Chinese patients. Subtype analysis revealed that the gut microbiota of PCOS patients with higher testosterone level (PCOS-HT) differed significantly from those with lower testosterone level (PCOS-LT). Prevotella, Blautia, Dialister, Ruminococcus_torques_group and UCG-002 were enhanced in PCOS-HT patients, while Alistipes, Dysosmobacter, Phocaeicola and Faecalibacterium were diminished. Importantly, a set of eight genera effectively differentiated PCOS-HT patients from PCOS-LT patients with an AUC of 0.95.

Interpretation: This systematic anatomization of gut microbiota revealed the microbial characteristics of PCOS patients, particularly those with different testosterone level, thus laying the foundations for further research into pathogenesis of PCOS, and the development of effective diagnostic, treatment, and intervention strategies.

Funding: This work was supported by the National Natural Science Foundation of China (No. 81973217, 82260304), the Hainan Province Clinical Medical Center (QWYH202175), and the Specific Research Fund of The Innovation Platform for Academicians of Hainan Province (YSPTZX202311).

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多囊卵巢综合征妇女的肠道微生物群:基于公开数据的个体分析。
背景:多囊卵巢综合征(PCOS多囊卵巢综合征(PCOS)是影响全球众多女性的一种常见内分泌疾病。肠道微生物菌群失调与多囊卵巢综合征的发生有关;然而,对多囊卵巢综合征患者肠道微生物菌群特征的研究仍然有限,尤其是来自不同地区和睾酮水平不同的患者。此外,目前还不清楚肠道微生物群是否有助于区分不同的多囊卵巢综合症亚型:我们检索了 2010 年 1 月 1 日至 2024 年 5 月 1 日的四个电子数据库(PubMed、Web of Science、Cochrane Library 和 ClinicalTrials.gov)。这项综合分析包括提供多囊卵巢综合症患者肠道微生物群原始数据的研究。我们重新分析了不同地区、不同睾酮水平的多囊卵巢综合征患者肠道微生物群的特征:符合纳入标准的 14 篇文献被纳入合并分析。根据来自 948 人的数据,我们发现多囊卵巢综合征组和健康对照组(HC)的α-多样性无显著差异。然而,与健康人相比,多囊卵巢综合症患者的肠道微生物群组成却有所不同。具体来说,多囊卵巢综合症妇女体内的镰刀菌(Fusobacterium)、反刍球菌(Ruminococcus_gnavus_group)和志贺氏埃希氏菌(Escherichia-Shigella)增加了,而Dysosmobacter、Schaedlerella、Merdimonas、Clostridiisalibacter、Flintibacter等减少了。从地区来看,Alistipes 主要富集于欧洲患者,而 Blautia 和 Roseburia 在中国患者中更为丰富。亚型分析表明,睾酮水平较高的多囊卵巢综合症患者(PCOS-HT)与睾酮水平较低的患者(PCOS-LT)的肠道微生物群存在显著差异。PCOS-HT患者的前驱菌(Prevotella)、Blautia、Dialister、Ruminococcus_torques_group和UCG-002增多,而Alistipes、Dysosmobacter、Phocaeicola和Faecalibacterium减少。重要的是,一组 8 个菌属能有效区分 PCOS-HT 患者和 PCOS-LT 患者,AUC 为 0.95:这项肠道微生物群的系统解剖学研究揭示了多囊卵巢综合征患者的微生物特征,尤其是那些睾酮水平不同的患者,从而为进一步研究多囊卵巢综合征的发病机制、制定有效的诊断、治疗和干预策略奠定了基础:本研究得到了国家自然科学基金(81973217,82260304)、海南省临床医学中心(QWYH202175)和海南省院士创新平台专项科研基金(YSPTZX202311)的资助。
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来源期刊
EClinicalMedicine
EClinicalMedicine Medicine-Medicine (all)
CiteScore
18.90
自引率
1.30%
发文量
506
审稿时长
22 days
期刊介绍: eClinicalMedicine is a gold open-access clinical journal designed to support frontline health professionals in addressing the complex and rapid health transitions affecting societies globally. The journal aims to assist practitioners in overcoming healthcare challenges across diverse communities, spanning diagnosis, treatment, prevention, and health promotion. Integrating disciplines from various specialties and life stages, it seeks to enhance health systems as fundamental institutions within societies. With a forward-thinking approach, eClinicalMedicine aims to redefine the future of healthcare.
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