Ana Mateos-Maroto, Meiyu Gai, Maximilian Brückner, Volker Mailänder, Svenja Morsbach, Katharina Landfester
{"title":"Controlled Functionalization Strategy of Proteins Preserves their Structural Integrity While Binding to Nanocarriers (Adv. Mater. Interfaces 30/2024)","authors":"Ana Mateos-Maroto, Meiyu Gai, Maximilian Brückner, Volker Mailänder, Svenja Morsbach, Katharina Landfester","doi":"10.1002/admi.202470073","DOIUrl":null,"url":null,"abstract":"<p><b>Protein Functionalization</b></p><p>Modification of proteins is often required for their use as targeting agents. However, chemical over-modification can lead to the loss of their native structure and thus affect their functionality. Based on NHS ester chemistry, in this article 2400472 by Katharina Landfester and co-workers, a minimal protein modification strategy including detailed characterization is developed, keeping the secondary structure intact and allowing their further attachment to nanocarriers via click chemistry.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":"11 30","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202470073","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Materials Interfaces","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/admi.202470073","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Protein Functionalization
Modification of proteins is often required for their use as targeting agents. However, chemical over-modification can lead to the loss of their native structure and thus affect their functionality. Based on NHS ester chemistry, in this article 2400472 by Katharina Landfester and co-workers, a minimal protein modification strategy including detailed characterization is developed, keeping the secondary structure intact and allowing their further attachment to nanocarriers via click chemistry.
期刊介绍:
Advanced Materials Interfaces publishes top-level research on interface technologies and effects. Considering any interface formed between solids, liquids, and gases, the journal ensures an interdisciplinary blend of physics, chemistry, materials science, and life sciences. Advanced Materials Interfaces was launched in 2014 and received an Impact Factor of 4.834 in 2018.
The scope of Advanced Materials Interfaces is dedicated to interfaces and surfaces that play an essential role in virtually all materials and devices. Physics, chemistry, materials science and life sciences blend to encourage new, cross-pollinating ideas, which will drive forward our understanding of the processes at the interface.
Advanced Materials Interfaces covers all topics in interface-related research:
Oil / water separation,
Applications of nanostructured materials,
2D materials and heterostructures,
Surfaces and interfaces in organic electronic devices,
Catalysis and membranes,
Self-assembly and nanopatterned surfaces,
Composite and coating materials,
Biointerfaces for technical and medical applications.
Advanced Materials Interfaces provides a forum for topics on surface and interface science with a wide choice of formats: Reviews, Full Papers, and Communications, as well as Progress Reports and Research News.