Serum cholesterol and interleukin-10 are associated with post-intracerebral hemorrhage depression in patients with acute primary supratentorial intracerebral hemorrhage

IF 1.3 Q4 CLINICAL NEUROLOGY Brain Hemorrhages Pub Date : 2024-10-01 DOI:10.1016/j.hest.2024.05.006
Liping Wei , Zhihua Liu , Huimin Cai , Huihong Tian , Jie Tan , Yuhu Zhang , Lijuan Wang , Yuyuan Gao , Jian Wang , Limin Wang
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Abstract

Objectives

This study explores the correlation between serum cholesterol, interleukin-10 (IL-10), macrophage migration inhibitory factor (MIF), and post-intracerebral hemorrhage (post-ICH) depression in patients with acute ICH.

Methods

35 patients with acute primary supratentorial ICH were recruited. Serum cholesterol, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), and low-density lipoprotein cholesterol (LDLC), IL-10, and MIF were measured in the first morning after admission. Additionally, a 24-item Hamilton Depression Scale (HAMD-24) was used to detect depressive symptoms one week after admission. HAMD scores ≥ 8 indicated a diagnosis of post-ICH depression.

Results

The levels of TC were significantly lower in ICH patients with depression compared to those without [169.26(139.23–215.67) mg/dL vs. 200.46(182.81–224.74) mg/dL, P = 0.010]. Similarly, levels of LDLC [102.18(78.39–137.28) mg/dL vs. 135.14(120.22–170.63) mg/dL, P = 0.001] and IL-10 [17.56(16.03–22.52) pg/mL vs. 31.17(23.42–37.53) pg/mL, P = 0.001] were also lower in patients with post-ICH depression. Furthermore, the levels of TC (r = -0.433, P = 0.009), TG (r = -0.345, P = 0.043), LDLC (r = -0.549, P = 0.001), and IL-10 levels (r = -0.603, P < 0.001) showed negative correlations with the HAMD scores. Logistic regression analysis indicated that higher IL-10 levels (OR = 0.847, 95 % CI = 0.717–0.999, P = 0.049) were indicative of protection against post-ICH depression in the acute phase.

Conclusion

Lower levels of TC, LDLC, and IL-10 were associated with post-ICH depression during the acute phase. Furthermore, decreased levels of IL-10 may serve as a promising predictor for post-ICH depression.
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血清胆固醇和白细胞介素-10 与急性原发性颅内上出血患者脑出血后抑郁有关
目的 本研究探讨了急性ICH患者血清胆固醇、白细胞介素-10(IL-10)、巨噬细胞迁移抑制因子(MIF)与脑出血后(ICH)抑郁之间的相关性。入院后第一天早晨测量血清胆固醇,包括总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)和低密度脂蛋白胆固醇(LDLC)、IL-10和MIF。此外,入院一周后,使用 24 项汉密尔顿抑郁量表(HAMD-24)检测抑郁症状。结果 患有抑郁症的 ICH 患者 TC 水平明显低于未患抑郁症的患者 [169.26(139.23-215.67) mg/dL vs. 200.46(182.81-224.74) mg/dL, P = 0.010]。同样,ICH 后抑郁症患者的 LDLC [102.18(78.39-137.28) mg/dL vs. 135.14(120.22-170.63) mg/dL, P = 0.001]和 IL-10 [17.56(16.03-22.52) pg/mL vs. 31.17(23.42-37.53) pg/mL, P = 0.001]水平也较低。此外,TC(r = -0.433,P = 0.009)、TG(r = -0.345,P = 0.043)、LDLC(r = -0.549,P = 0.001)和 IL-10 水平(r = -0.603,P <0.001)与 HAMD 评分呈负相关。逻辑回归分析表明,较高的IL-10水平(OR = 0.847,95 % CI = 0.717-0.999,P = 0.049)表明在急性期可预防ICH后抑郁。此外,IL-10水平的降低可作为ICH后抑郁的预测因子。
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来源期刊
Brain Hemorrhages
Brain Hemorrhages Medicine-Surgery
CiteScore
2.90
自引率
0.00%
发文量
52
审稿时长
22 days
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