Molecularly imprinted polymer sensors for biomarker detection in cardiovascular diseases

IF 3.6 3区化学 Q2 CHEMISTRY, ANALYTICAL Analyst Pub Date : 2024-10-30 DOI:10.1039/D4AN01103A

Wenteng Tang, Junlei Han, Wenhong Zhang, Huimin Li, Jun Chen, Wei Song and Li Wang

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Abstract

Cardiovascular diseases (CVDs) are recognized as a significant threat to global health. The rapid, sensitive, and precise measurement of relevant biomarkers is essential for the timely diagnosis of CVDs. Molecularly imprinted polymers (MIPs), which act as artificial receptor recognition materials, have been extensively utilized in the detection of CVD biomarkers. Their widespread application is due to their cost-effectiveness, physical and chemical stability, straightforward preparation processes, and excellent compatibility with various sensor types. This review introduces the principles of MIP sensors in combination with electrochemical, optical, thermal transfer, and acoustic detection techniques for detecting CVD-related biomarkers. It then discusses methods developed over the past decade for detecting biomarkers of three major CVDs—coronary artery disease (CAD), acute myocardial infarction (AMI), and heart failure (HF)—using MIP sensors. Finally, the review summarizes the potential of MIP sensors in CVD biomarker detection and provides an outlook on future research directions.

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用于心血管疾病生物标记物检测的分子印迹聚合物传感器

心血管疾病（CVDs）被认为是对全球健康的重大威胁。快速、灵敏、精确地测量相关生物标记物对于及时诊断心血管疾病至关重要。作为人工受体识别材料的分子印迹聚合物（MIPs）已被广泛用于心血管疾病生物标志物的检测。分子印迹聚合物具有成本效益高、物理和化学性质稳定、制备过程简单以及与各种类型的传感器具有良好的兼容性等优点，因此得到了广泛的应用。本综述介绍了 MIP 传感器与电化学、光学、热传递和声学检测技术相结合用于检测气相沉积相关生物标记物的原理。然后讨论了过去十年中开发的利用 MIP 传感器检测三大心血管疾病（冠心病 (CAD)、急性心肌梗塞 (AMI) 和心力衰竭 (HF)）生物标记物的方法。最后，综述总结了 MIP 传感器在心血管疾病生物标记物检测方面的潜力，并展望了未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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