Zhibin Zhou, Mengzhen Zhao, Huaqiang Fang, Ziyue Lin, Xinrui Zheng, Yi Zhuo, Zimeng Li, Weiming Zhou, Xiaolei Wang
{"title":"Conductive hydrogel with responsive release of Herbal-Derived carbon dots for neurovascular reconstruction in diabetic critical limb ischemia","authors":"Zhibin Zhou, Mengzhen Zhao, Huaqiang Fang, Ziyue Lin, Xinrui Zheng, Yi Zhuo, Zimeng Li, Weiming Zhou, Xiaolei Wang","doi":"10.1016/j.cej.2024.157265","DOIUrl":null,"url":null,"abstract":"Diabetic critical limb ischemia (CLI), a common complication of diabetes with high morbidity and amputation rates, has seriously endangered the patients’ health and quality of life. Diabetic CLI is commonly characterized by inflammatory imbalance, vasculopathy, and neuropathy, which significantly impede tissue regeneration. Most biomaterials offer limited angiogenic functions, of which neuropathy treatment is still in its infancy. Herein, we report a composite conductive hydrogel (MSC@COP) by combining the salidroside-derived carbon dots (CDs)-embedded magnesium silicate nanoflowers (MSC) with the PEDOT:PSS-based hydrogel. Responding to the low-pH environment of diabetic CLI, CDs and magnesium ions (Mg<sup>2+</sup>) are released to scavenge reactive oxygen species in the ischemic microenvironment and promote the M1-to-M2 polarization of macrophages to reshape the inflammatory environment. Meanwhile, the high conductivity of the hydrogel conferred by PEDOT:PSS not only repairs the endogenous electric field but also synergizes with CDs and Mg<sup>2+</sup> to inhibit Schwann cell pyroptosis, improve the recruitment of Schwann cells, consequently promoting the dual reconstruction of neural and vascular tissues.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":null,"pages":null},"PeriodicalIF":13.3000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Engineering Journal","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.cej.2024.157265","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Diabetic critical limb ischemia (CLI), a common complication of diabetes with high morbidity and amputation rates, has seriously endangered the patients’ health and quality of life. Diabetic CLI is commonly characterized by inflammatory imbalance, vasculopathy, and neuropathy, which significantly impede tissue regeneration. Most biomaterials offer limited angiogenic functions, of which neuropathy treatment is still in its infancy. Herein, we report a composite conductive hydrogel (MSC@COP) by combining the salidroside-derived carbon dots (CDs)-embedded magnesium silicate nanoflowers (MSC) with the PEDOT:PSS-based hydrogel. Responding to the low-pH environment of diabetic CLI, CDs and magnesium ions (Mg2+) are released to scavenge reactive oxygen species in the ischemic microenvironment and promote the M1-to-M2 polarization of macrophages to reshape the inflammatory environment. Meanwhile, the high conductivity of the hydrogel conferred by PEDOT:PSS not only repairs the endogenous electric field but also synergizes with CDs and Mg2+ to inhibit Schwann cell pyroptosis, improve the recruitment of Schwann cells, consequently promoting the dual reconstruction of neural and vascular tissues.
期刊介绍:
The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.