Effect of Phytosterols on Serum Levels of C-Reactive Protein: A Time- and Dose-Response Meta-analysis of Randomized Controlled Trial.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE High Blood Pressure & Cardiovascular Prevention Pub Date : 2024-10-30 DOI:10.1007/s40292-024-00686-6
Saeed Aslani, Mohammad Masoud Eslami, Ghasem Fakourizad, Ahmad Faisal Faiz, Kayhan Mohammadi, Omid Dehghan, Danyal Imani, Alireza Abbaspour, Tannaz Jamialahmadi, Bahman Razi, Amirhossein Sahebkar
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Abstract

Introduction: Phytosterols are recognized for their cholesterol-reducing effects and are commonly used as dietary supplements or added to foods due to their potential cardiovascular benefits. However, evidence regarding the impact of phytosterol supplementation on inflammatory markers remains inconclusive.

Aim: This systematic review and meta-analysis aim to evaluate the effect of phytosterols in reducing levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP).

Methods: A systematic literature search of the primary databases was conducted up to May 2024 to identify eligible studies. The measurement of effect sizes was determined using WMD (weighted mean difference) and 95% CI.

Results: For the meta-analysis, 14 publications (19 study arms) for hs-CRP and 10 publications (16 study arms) for CRP were included. The pooled analysis showed that the administration of phytosterol did not significantly reduce CRP compared to control with WMD= -0.04 mg/l (95% CI: -0.28 to 0.20, P = 0.74). However, phytosterol supplementation significantly decreased the hs-CRP level compared to the control group with WMD of -0.25 mg/l (95% CI: -0.42 to -0.07, P = 0.006). The WMD for hs-CRP reduction was - 0.36 mg/l (95% CI: -0.53 to -0.18, P < 0.001) for supplementation with a phytosterol dose ≥ 2000 mg/day compared to the control group.

Conclusions: Phytosterol supplementation may be effective in reducing hs-CRP levels.

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植物甾醇对血清 C 反应蛋白水平的影响:随机对照试验的时间和剂量反应元分析。
简介:植物甾醇具有降低胆固醇的作用,由于其对心血管的潜在益处,植物甾醇通常被用作膳食补充剂或添加到食品中。目的:本系统综述和荟萃分析旨在评估植物甾醇在降低 C 反应蛋白 (CRP) 和高敏 CRP (hs-CRP) 水平方面的效果:方法:对截至 2024 年 5 月的主要数据库进行了系统性文献检索,以确定符合条件的研究。采用 WMD(加权平均差)和 95% CI 测定效应大小:在荟萃分析中,共纳入了 14 篇 hs-CRP 研究文献(19 个研究臂)和 10 篇 CRP 研究文献(16 个研究臂)。汇总分析显示,与对照组相比,服用植物甾醇并不能显著降低 CRP,WMD=-0.04 毫克/升(95% CI:-0.28 至 0.20,P = 0.74)。然而,与对照组相比,补充植物甾醇可显著降低 hs-CRP 水平,WMD=-0.25 毫克/升(95% CI:-0.42 至 -0.07,P = 0.006)。hs-CRP降低的WMD为-0.36毫克/升(95% CI:-0.53至-0.18,P 结论:植物甾醇补充剂可能是一种有效的抗氧化剂:补充植物甾醇可有效降低 hs-CRP 水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.70
自引率
3.30%
发文量
57
期刊介绍: High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes:   Invited ''State of the Art'' reviews.  Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.
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