A microsystem for in vivo wireless monitoring of plastic biliary stents using magnetoelastic sensors.

IF 7.3 1区 工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Microsystems & Nanoengineering Pub Date : 2024-10-31 DOI:10.1038/s41378-024-00772-8
Ramprasad M Nambisan, Scott R Green, Richard S Kwon, Grace H Elta, Yogesh B Gianchandani
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Abstract

With an interest in monitoring the patency of stents that are used to treat strictures in the bile duct, this paper reports the investigation of a wireless sensing system to interrogate a microsensor integrated into the stent. The microsensor is comprised of a 28-μm-thick magnetoelastic foil with 8.25-mm length and 1-mm width. Magnetic biasing is provided by permanent magnets attached to the foil. These elements are incorporated into a customized 3D polymeric package. The system electromagnetically excites the magnetoelastic resonant sensor and measures the resulting signal. Through shifts in resonant frequency and quality factor, the sensor is intended to provide an early indication of sludge accumulation in the stent. This work focuses on challenges associated with sensor miniaturization and placement, wireless range, drive signal feedthrough, and clinical use. A swine specimen in vivo experiment is described. Following endoscopic implantation of the sensor enabled plastic stent into the bile duct, at a range of approximately 17 cm, the signal-to-noise ratio of ~106 was observed with an interrogation time of 336 s. These are the first reported signals from a passive wireless magnetoelastic sensor implanted in a live animal.

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利用磁弹性传感器对塑料胆道支架进行体内无线监测的微型系统。
为了监测用于治疗胆管狭窄的支架的通畅性,本文报告了对一种无线传感系统的研究,该系统用于询问集成在支架中的微型传感器。微型传感器由长 8.25 毫米、宽 1 毫米、厚 28 微米的磁弹性箔组成。磁偏压由附着在箔上的永久磁铁提供。这些元件被集成到一个定制的三维聚合物封装中。系统以电磁方式激发磁弹性谐振传感器,并测量由此产生的信号。通过共振频率和品质因数的变化,传感器可及早显示支架中的污泥积聚情况。这项工作的重点是与传感器微型化和放置、无线范围、驱动信号馈通和临床使用相关的挑战。文中描述了一个猪标本体内实验。在内窥镜下将启用传感器的塑料支架植入胆管后,在约 17 厘米的范围内,观察到信噪比约为 106,询问时间为 336 秒。这是首次报道植入活体动物体内的无源无线磁弹性传感器发出的信号。
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来源期刊
Microsystems & Nanoengineering
Microsystems & Nanoengineering Materials Science-Materials Science (miscellaneous)
CiteScore
12.00
自引率
3.80%
发文量
123
审稿时长
20 weeks
期刊介绍: Microsystems & Nanoengineering is a comprehensive online journal that focuses on the field of Micro and Nano Electro Mechanical Systems (MEMS and NEMS). It provides a platform for researchers to share their original research findings and review articles in this area. The journal covers a wide range of topics, from fundamental research to practical applications. Published by Springer Nature, in collaboration with the Aerospace Information Research Institute, Chinese Academy of Sciences, and with the support of the State Key Laboratory of Transducer Technology, it is an esteemed publication in the field. As an open access journal, it offers free access to its content, allowing readers from around the world to benefit from the latest developments in MEMS and NEMS.
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