Prognostic values of combined ratios of white blood cells in glioma: a systematic review and meta-analysis.

IF 2.5 3区 医学 Q2 CLINICAL NEUROLOGY Neurosurgical Review Pub Date : 2024-10-31 DOI:10.1007/s10143-024-03064-x
JiaNuo Zhou, Botao Tan, Feng Gao
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Abstract

Gliomas, the most prevalent type of neurological tumor, pose a challenging prognosis for patients. Recent studies have underscored the importance of inflammatory markers such as the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR) in predicting the prognosis of gliomas. We undertook a thorough meta-analysis to elucidate the role of these inflammatory markers in forecasting the prognosis of glioma patients. We extracted hazard ratios (HR) and their corresponding 95% confidence intervals (95% CI) from each study for analysis. To assess heterogeneity and identify influential studies, we conducted sensitivity analysis. Subgroup analysis was performed to investigate sources of heterogeneity, and we employed Egger's test to evaluate publication bias in the meta-analysis. Higher NLR levels were associated with shorter overall survival (HR = 1.46, 95% CI: 1.33-1.60) and progression-free survival (HR = 1.24, 95% CI: 1.04-1.48). There was no significant correlation between PLR levels and overall survival (HR = 1.01, 95% CI: 1.00-1.01) or progression-free survival (HR = 1.00, 95% CI: 0.98-1.02) in glioma patients. Elevated MLR levels were associated with decreased overall survival in glioma patients (HR = 1.78, 95% CI: 1.36-2.34). SII levels did not show any significant association with overall or progression-free survival in glioma patients (HR = 1.00, 95% CI: 0.99-1.01).In the sensitivity analysis, two studies potentially contributed to the instability. Subgroup analyses showed patient population and area were identified as potential sources of heterogeneity. Egger's test showed that there was publication bias in the relationship between NLR and PLR and overall survival (P < 0.05).All randomized controlled models, except for these, were not affected by publication bias. NLR and MLR are two reliable indicators of inflammation in the prognosis of glioma patients; PLR and SII do not have significant value in the prognosis of glioma patients.

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胶质瘤白细胞综合比率的预后价值:系统综述和荟萃分析。
胶质瘤是神经系统肿瘤中最常见的一种,对患者的预后具有挑战性。最近的研究强调了中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)和单核细胞/淋巴细胞比值(MLR)等炎症标志物在预测胶质瘤预后方面的重要性。我们进行了一项全面的荟萃分析,以阐明这些炎症标志物在预测胶质瘤患者预后方面的作用。我们从每项研究中提取了危险比(HR)及其相应的 95% 置信区间(95% CI)进行分析。为了评估异质性并确定有影响的研究,我们进行了敏感性分析。我们进行了亚组分析以调查异质性的来源,并采用Egger检验来评估荟萃分析中的发表偏倚。较高的 NLR 水平与较短的总生存期(HR = 1.46,95% CI:1.33-1.60)和无进展生存期(HR = 1.24,95% CI:1.04-1.48)相关。在胶质瘤患者中,PLR水平与总生存期(HR = 1.01,95% CI:1.00-1.01)或无进展生存期(HR = 1.00,95% CI:0.98-1.02)之间无明显相关性。MLR水平升高与胶质瘤患者总生存率下降有关(HR = 1.78,95% CI:1.36-2.34)。SII水平与胶质瘤患者的总生存期或无进展生存期无明显关系(HR = 1.00,95% CI:0.99-1.01)。亚组分析显示,患者人群和地区被确定为潜在的异质性来源。Egger检验显示,NLR和PLR与总生存率之间的关系存在发表偏倚(P
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来源期刊
Neurosurgical Review
Neurosurgical Review 医学-临床神经学
CiteScore
5.60
自引率
7.10%
发文量
191
审稿时长
6-12 weeks
期刊介绍: The goal of Neurosurgical Review is to provide a forum for comprehensive reviews on current issues in neurosurgery. Each issue contains up to three reviews, reflecting all important aspects of one topic (a disease or a surgical approach). Comments by a panel of experts within the same issue complete the topic. By providing comprehensive coverage of one topic per issue, Neurosurgical Review combines the topicality of professional journals with the indepth treatment of a monograph. Original papers of high quality are also welcome.
期刊最新文献
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