Portable sensing of hydrogen peroxide using MOF-based nanozymes

IF 7 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Food Research International Pub Date : 2024-10-28 DOI:10.1016/j.foodres.2024.115272

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Abstract

Hydrogen peroxide (H₂O₂) is extensively used in water treatment and food preservation for its pathogen-killing efficacy. Excessive H₂O₂ intake, however, can lead to poisoning with symptoms such as abdominal pain and breathing difficulties. Additionally, small amounts of H₂O₂ may be generated during food preservation, necessitating careful control to meet safety regulations. Real-time detection of H₂O₂ is crucial for process safety and compliance. In this study, a Zr-MOF-based colorimetric fluorescent nanozyme sensor (NH₂-UiO-67(Zr/Cu)) along with a smartphone-assisted portable device were developed for detecting H₂O₂. The sensor, NH₂-UiO-67(Zr/Cu), combines the stable structural properties of Zr-MOF with ligand-generated fluorescence and exhibits peroxidase-like activity. The sensor demonstrated a detection range of 0–1000 μM, with limits of detection (LOD) of 0.0057 μM for the colorimetric assay and 0.0020 μM for the fluorescence assay. Additionally, we designed and developed a portable, smartphone-assisted device using 3D printing technology. This device offers a detection range of 0–750 μM, with LODs of 0.0093 μM in colorimetric mode and 0.0311 μM in fluorescence mode. The developed colorimetric fluorescent nanozyme sensor and portable device show significant potential for the rapid on-site detection of H₂O₂, offering a more convenient and reliable approach for quick identification of analytes in practical applications.

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利用基于 MOF 的纳米酶对过氧化氢进行便携式传感

过氧化氢（H2O2）具有杀灭病原体的功效，被广泛用于水处理和食品保鲜。然而，过量摄入 H2O2 会导致中毒，出现腹痛和呼吸困难等症状。此外，在食品保鲜过程中可能会产生少量 H2O2，因此必须小心控制，以符合安全规定。H2O2 的实时检测对过程安全和合规性至关重要。本研究开发了一种基于 Zr-MOF 的比色荧光纳米酶传感器（NH2-UiO-67(Zr/Cu)）和一种智能手机辅助便携式设备，用于检测 H2O2。传感器 NH2-UiO-67(Zr/Cu) 结合了 Zr-MOF 的稳定结构特性和配体产生的荧光，并表现出类似过氧化物酶的活性。该传感器的检测范围为 0-1000 μM，比色检测的检测限（LOD）为 0.0057 μM，荧光检测的检测限（LOD）为 0.0020 μM。此外，我们还利用 3D 打印技术设计并开发了一种便携式智能手机辅助设备。该装置的检测范围为 0-750 μM，比色模式的 LOD 为 0.0093 μM，荧光模式的 LOD 为 0.0311 μM。所开发的比色法荧光纳米酶传感器和便携式装置在现场快速检测 H2O2 方面显示出巨大的潜力，为实际应用中快速鉴定分析物提供了一种更方便、更可靠的方法。

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来源期刊

Food Research International 工程技术-食品科技

CiteScore

12.50

自引率

7.40%

发文量

1183

审稿时长

79 days

期刊介绍： Food Research International serves as a rapid dissemination platform for significant and impactful research in food science, technology, engineering, and nutrition. The journal focuses on publishing novel, high-quality, and high-impact review papers, original research papers, and letters to the editors across various disciplines in the science and technology of food. Additionally, it follows a policy of publishing special issues on topical and emergent subjects in food research or related areas. Selected, peer-reviewed papers from scientific meetings, workshops, and conferences on the science, technology, and engineering of foods are also featured in special issues.