The gut microbiome in patients with Cushing's disease affects depression- and anxiety-like behavior in mice.

IF 13.8 1区生物学 Q1 MICROBIOLOGY Microbiome Pub Date : 2024-11-01 DOI:10.1186/s40168-024-01939-1

Ding Nie, Dawei Wang, Zhenhua Wang, Qiuyue Fang, Hongyun Wang, Weiyan Xie, Chuzhong Li, Yazhuo Zhang

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Abstract

Background: Depression and anxiety significantly impact the quality of life in individuals with Cushing's disease (CD), which originates from pituitary neuroendocrine tumors (PitNETs), yet our understanding of the underlying mechanisms is limited. There is substantial evidence linking gut microbes to depression, anxiety, and endocrinology.

Results: The gut bacterial phenotype of patients with Cushing's disease was significantly different from that of the control group, and when the mice were treated with fecal bacteria from these patients, both anxiety- and depression-like behavior were significantly increased. However, this effect can be alleviated by supplementing with 2-(14, 15-epoxyeicosatrienoyl) glycerol (2-14,15-EG) which was found at reduced levels in the peripheral blood of mice treated with coprofecal bacteria from Cushing's disease. In this process, the effects of hormone levels and immune factors were not significant. In addition, in an animal model, corticosterone has been observed to affect behavioral changes in mice through gut microbiota composition, clarifying the cause-and-effect relationship between hormones, microbiota, and behavior. Finally, there was no significant difference in gut microbiome composition and its effects on mouse behavior in patients with Cushing's disease with different levels of depression and anxiety.

Conclusions: In summary, this research enhances our current understanding of how gut microbes in patients with Cushing's disease contribute to depression and anxiety, offering novel insights for clinical treatment approaches. Video Abstract.

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库欣病患者的肠道微生物群会影响小鼠的抑郁和焦虑行为。

背景：抑郁和焦虑严重影响着库欣病（CD）患者的生活质量，而库欣病是由垂体神经内分泌肿瘤（PitNETs）引起的，但我们对其潜在机制的了解却很有限。有大量证据表明肠道微生物与抑郁、焦虑和内分泌有关：库欣病患者的肠道细菌表型与对照组有显著差异，用这些患者的粪便细菌处理小鼠时，焦虑和抑郁样行为都会显著增加。然而，通过补充 2-（14,15-环氧洋三烯酰基）甘油（2-14,15-EG）可减轻这种影响，在使用库欣病共排泄物细菌治疗的小鼠外周血中，2-（14,15-环氧洋三烯酰基）甘油的含量有所降低。在这一过程中，激素水平和免疫因素的影响并不显著。此外，在一个动物模型中，观察到皮质酮通过肠道微生物群的组成影响小鼠的行为变化，明确了激素、微生物群和行为之间的因果关系。最后，不同抑郁和焦虑程度的库欣病患者的肠道微生物群组成及其对小鼠行为的影响没有明显差异：总之，这项研究加深了我们目前对库欣病患者肠道微生物如何导致抑郁和焦虑的理解，为临床治疗方法提供了新的见解。视频摘要

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来源期刊

Microbiome MICROBIOLOGY-

CiteScore

21.90

自引率

2.60%

发文量

198

审稿时长

4 weeks

期刊介绍： Microbiome is a journal that focuses on studies of microbiomes in humans, animals, plants, and the environment. It covers both natural and manipulated microbiomes, such as those in agriculture. The journal is interested in research that uses meta-omics approaches or novel bioinformatics tools and emphasizes the community/host interaction and structure-function relationship within the microbiome. Studies that go beyond descriptive omics surveys and include experimental or theoretical approaches will be considered for publication. The journal also encourages research that establishes cause and effect relationships and supports proposed microbiome functions. However, studies of individual microbial isolates/species without exploring their impact on the host or the complex microbiome structures and functions will not be considered for publication. Microbiome is indexed in BIOSIS, Current Contents, DOAJ, Embase, MEDLINE, PubMed, PubMed Central, and Science Citations Index Expanded.