Similarities and differences between chronic primary pain and depression in brain activities: Evidence from resting-state microstates and auditory Oddball task.

Abstract

Background: In 2019, the International Association for the Study of Pain introduced the concept of 'chronic primary pain (CPP)', characterized by persistent non-organic pain with emotional and functional abnormalities. Underdiagnosed and linked to depression, CPP has poorly understood neural characteristics. Electroencephalogram (EEG) microstates enable detailed examination of brain network dynamics at the millisecond level. Incorporating task-related EEG features offers a comprehensive neurophysiological signature of brain dysfunction, facilitating exploration of potential neural mechanisms.

Methods: This study employed resting-state and task-related auditory Oddball EEG paradigm to evaluate 20 healthy controls, 20 patients with depression, and 20 patients with CPP. An 8-minute recording of resting-state EEG was conducted to identify four typical microstates (A-D). Additionally, power spectral density (PSD) features were examined during an auditory Oddball paradigm.

Results: Both CPP and Major Depressive Disorder (MDD) patients exhibited reduced occurrence rate and transition probabilities of other microstates to microstate C during resting-state EEG. Furthermore, more pronounced increase in Gamma PSD was observed in the occipital region of CPP during the Oddball task. In CPP, both resting-state microstate C and task-related Gamma PSD correlated with pain and emotional indicators. Notably, microstate C occurrence positively correlated with occipital Gamma PSD in MDD.

Conclusion: Conclusively, both CPP and MDD display dynamic abnormalities within the salient network, closely associated with pain and depressive symptoms in CPP. Unlike MDD, CPPs' dynamic network changes appear unrelated to perceptual integration function, indicating differing microstate functional impacts. Combining resting-state microstates and Oddball tasks may offer a promising avenue for identifying potential biomarkers in objectively assessing chronic primary pain.