{"title":"A butyrolactone derivative from marine-derived fungal strain <i>Aspergillus terreus</i> BTBU20211037.","authors":"Xinwan Zhang, Renming Jia, Jinpeng Yang, Zhijun Song, Xiuli Xu, Fuhang Song","doi":"10.1080/14786419.2024.2422515","DOIUrl":null,"url":null,"abstract":"<p><p>The secondary metabolites of marine-derived fungal strain, <i>Aspergillus terreus</i> BTBU20211037, isolated from Qinhuangdao coast were investigated. Thirteen compounds were isolated and identified, including one new compound, butyrolactone J (<b>1</b>), and twelve known compounds, butyrolactone I (<b>2</b>), butyrolactone VI (<b>3</b>), aspernolide B (<b>4</b>), aspernolide A (<b>5</b>), 7'-hydroxybutyrolactone III (<b>6</b>), methyl asterrate (<b>7</b>), methyl dichloroasterrate (<b>8</b>), sulochrin (<b>9</b>), methyl 6-acetyl-4-methoxy-5,7,8-trihydroxynaphthalene-2-carboxylate (<b>10</b>), serantrypinone (<b>11</b>), alantrypinone (<b>12</b>), and territrem A (<b>13</b>). The structures of the compounds were elucidated by HRESIMS, NMR, and ECD analysis. Compounds <b>1</b>, <b>10</b>, and <b>13</b> showed inhibitory effects against <i>Staphylococcus aureus</i> ATCC 25923 with minimal inhibitory concentrations of 12.5, 25, and 100 μg/mL, respectively.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2422515","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
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Abstract
The secondary metabolites of marine-derived fungal strain, Aspergillus terreus BTBU20211037, isolated from Qinhuangdao coast were investigated. Thirteen compounds were isolated and identified, including one new compound, butyrolactone J (1), and twelve known compounds, butyrolactone I (2), butyrolactone VI (3), aspernolide B (4), aspernolide A (5), 7'-hydroxybutyrolactone III (6), methyl asterrate (7), methyl dichloroasterrate (8), sulochrin (9), methyl 6-acetyl-4-methoxy-5,7,8-trihydroxynaphthalene-2-carboxylate (10), serantrypinone (11), alantrypinone (12), and territrem A (13). The structures of the compounds were elucidated by HRESIMS, NMR, and ECD analysis. Compounds 1, 10, and 13 showed inhibitory effects against Staphylococcus aureus ATCC 25923 with minimal inhibitory concentrations of 12.5, 25, and 100 μg/mL, respectively.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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