Blue light-driven cell cycle arrest in thyroid cancer via Retinal-OPN3 complex.

IF 8.2 2区 生物学 Q1 CELL BIOLOGY Cell Communication and Signaling Pub Date : 2024-11-01 DOI:10.1186/s12964-024-01908-z
Changrui Zhao, Jiaqiang Bo, Tianyu Li, Jiameng Tian, Tian Long, Yingying He, Siyu Chen, Chang Liu
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Abstract

Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with a rising incidence. Traditional treatments, such as thyroidectomy and radiotherapy, often lead to significant side effects, including impaired thyroid function. Therefore, there is an urgent need for non-invasive therapeutic approaches. This study aims to explore the potential of photobiomodulation therapy (PBMT), a non-invasive treatment using specific wavelengths of light, in the management of PTC.

Methods: We investigated the effects of blue light PBMT on PTC cells, focusing on the Retinal-OPSIN 3 (OPN3) complex's role in mediating cellular responses. Blue light exposure was applied to PTC cells, and subsequent changes in cellular proliferation, cell cycle progression, and protein expression were analyzed. Statistical tests, including one-way ANOVA and t-tests, were used to evaluate the significance of the findings.

Results: Blue light exposure led to the dissociation of 11-cis-retinal from OPN3, resulting in the accumulation of all-trans retinal. This accumulation disrupted cellular proliferation pathways and induced G0/G1 cell cycle arrest in PTC cells. The Retinal-OPN3 complex was found to be a key mediator in these processes, demonstrating that thyroid cells can respond to specific light wavelengths and utilize their photoreceptive potential for therapeutic purposes.

Conclusions: Our findings suggest that PBMT, through the modulation of the Retinal-OPN3 complex, offers a promising non-invasive approach for treating PTC. This study highlights the therapeutic potential of light signal transduction in non-ocular tissues and opens new avenues for non-invasive cancer therapies.

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蓝光通过视网膜-OPN3复合物驱动甲状腺癌细胞周期停滞。
背景:甲状腺乳头状癌(PTC甲状腺乳头状癌(PTC)是最常见的甲状腺恶性肿瘤,发病率呈上升趋势。传统的治疗方法,如甲状腺切除术和放射治疗,往往会导致严重的副作用,包括甲状腺功能受损。因此,迫切需要非侵入性的治疗方法。本研究旨在探索光生物调节疗法(PBMT)在治疗 PTC 方面的潜力:我们研究了蓝光 PBMT 对 PTC 细胞的影响,重点是视网膜-OPSIN 3(OPN3)复合物在介导细胞反应中的作用。对 PTC 细胞进行蓝光照射,分析细胞增殖、细胞周期进展和蛋白质表达的后续变化。统计检验包括单因素方差分析和 t 检验,以评估研究结果的显著性:结果:蓝光照射导致 11-顺式视网膜与 OPN3 分离,造成全反式视网膜的积累。这种积累破坏了细胞增殖途径,并诱导 PTC 细胞的 G0/G1 细胞周期停滞。研究发现,视网膜-OPN3复合物是这些过程中的关键介质,这表明甲状腺细胞能对特定波长的光做出反应,并利用其感光潜能达到治疗目的:我们的研究结果表明,PBMT 通过调节视网膜-OPN3 复合物,为治疗 PTC 提供了一种前景广阔的非侵入性方法。这项研究凸显了非眼组织中光信号转导的治疗潜力,为非侵入性癌症疗法开辟了新途径。
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来源期刊
CiteScore
11.00
自引率
0.00%
发文量
180
期刊介绍: Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.
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