Analysis of retinal and choroidal microvasculature in systemic sclerosis using optical coherence tomography angiography: A systematic review and meta-analysis.

IF 2 4区 医学 Q2 OPHTHALMOLOGY Ophthalmic Research Pub Date : 2024-11-04 DOI:10.1159/000542413
Fatemeh Lohrasbi, Elaheh Karimi, Mahdi Gouravani, Shahnaz Fooladi Sarabi, Amirreza Mafi, Alireza Beikmarzehei, Hossein Sanjari Moghaddam, Mohammadamin Parsaei, Seyed Mehdi Tabatabaei, J Fernando Arevalo
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Abstract

Introduction: Optical coherence tomography angiography (OCTA) is an emerging technique to investigate retinal and choroidal microvascular alterations in patients with systemic sclerosis (SSc). This systematic review and meta-analysis aimed to evaluate the features of retinal and choroidal microvasculature using OCTA among SSc patients.

Methods: The methodology of the study was based on PRISMA guidelines. PubMed, Scopus, Web of Science, and Embase were searched systematically on November 25, 2023, for relevant studies utilizing OCTA as the main diagnostic tool to assess the retinal and choroidal microvasculature in SSc patients versus healthy controls. Random-effect or fixed model meta-analysis was used based on the heterogeneity of studies.

Results: Eleven observational comparative studies, including 366 patients with SSc and 350 healthy controls, conducted between 2020 and 2023, were included in this review. Meta-analysis findings revealed a significant decrease in vessel densities in both the superficial and deep capillary plexuses (SCP and DCP) among SSc patients compared to controls. However, there were no significant differences observed in the foveal avascular zone (FAZ) area and choriocapillary flow area (CCFA) between SSc patients and controls. Moreover, central macular thickness (CMT) consistently exhibited a decrease in SSc patients, while retinal nerve fiber layer (RNFL) thickness showed no significant differences. Although radial peripapillary capillary (RPC) vessel density, subfoveal choroidal thickness (CMT), and cup/disc ratio yielded mixed results, with some studies indicating significant changes in the SSc group, meta-analysis could not be performed due to variations in the OCTA machines used across the included studies.

Conclusion: This systematic review demonstrates retinal and choroidal microvascular abnormalities in SSc using OCTA. Longitudinal studies are needed to understand how these abnormalities evolve over time in patients with SSc and whether these abnormalities correlate with the clinical features of SSc.

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利用光学相干断层血管造影分析系统性硬化症患者的视网膜和脉络膜微血管:系统回顾和荟萃分析。
简介光学相干断层血管成像(OCTA)是一种新兴技术,可用于研究系统性硬化症(SSc)患者视网膜和脉络膜微血管的改变。本系统综述和荟萃分析旨在利用 OCTA 评估系统性硬化症患者视网膜和脉络膜微血管的特征:研究方法基于 PRISMA 指南。2023年11月25日,在PubMed、Scopus、Web of Science和Embase上系统检索了利用OCTA作为主要诊断工具评估SSc患者与健康对照组视网膜和脉络膜微血管的相关研究。根据研究的异质性,采用随机效应或固定模型荟萃分析:本综述共纳入了 11 项观察性比较研究,包括 366 名 SSc 患者和 350 名健康对照者,这些研究在 2020 年至 2023 年期间进行。元分析结果显示,与对照组相比,SSc 患者浅层和深层毛细血管丛(SCP 和 DCP)的血管密度均显著下降。然而,在眼窝无血管区(FAZ)面积和绒毛毛细血管流面积(CCFA)方面,SSc 患者和对照组之间没有观察到明显差异。此外,SSc 患者的黄斑中心厚度(CMT)持续下降,而视网膜神经纤维层(RNFL)厚度则无明显差异。虽然径向毛细血管周围(RPC)血管密度、眼底脉络膜厚度(CMT)和杯状/盘状比的结果参差不齐,一些研究表明SSc组有显著变化,但由于纳入研究的OCTA机器不同,因此无法进行荟萃分析:本系统性综述利用OCTA显示了SSc患者视网膜和脉络膜微血管的异常。需要进行纵向研究,以了解这些异常在 SSc 患者中是如何随时间演变的,以及这些异常是否与 SSc 的临床特征相关。
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来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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