Design and Synthesis of BODIPY and Its Application in Inhibiting Intestinal Flora

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-10-25 DOI:10.1021/acsomega.4c0488210.1021/acsomega.4c04882
Jinyao Xu, Hao Huang, Kewei Wang, Jiatao Zhu, Jiale Zhao, Yingshi Zhao, Jiangtao Yue, Cui Ying, Weijing Tao, Qiang Tong*, Li Quan* and Jinbing Xie*, 
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Abstract

BODIPY-based photosensitizers were synthesized and tested for antimicrobial photodynamic therapy, revealing structural modifications enhancing the photodynamic therapy (PDT) effects. This research may lead to new PDT strategies for treating bacterial infections, including those resistant to traditional antibiotics, and offers insights into the prevention and treatment of Alzheimer’s disease through gut microbiota regulation.

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BODIPY 的设计与合成及其在抑制肠道菌群中的应用
研究人员合成了基于 BODIPY 的光敏剂，并对其进行了抗菌光动力疗法测试，结果表明其结构修饰增强了光动力疗法（PDT）的效果。这项研究可能会为治疗细菌感染（包括对传统抗生素产生抗药性的细菌感染）带来新的光动力疗法策略，并为通过肠道微生物群调节预防和治疗阿尔茨海默病提供启示。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
ACS Applied Electronic Materials
ACS Applied Electronic Materials Multiple-
CiteScore
7.20
自引率
4.30%
发文量
567
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