3D Bioprinting in Cancer Modeling and Biomedicine: From Print Categories to Biological Applications

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-10-25 DOI:10.1021/acsomega.4c0605110.1021/acsomega.4c06051

Jianye Yang, Le Wang, Ruimei Wu, Yanan He, Yu Zhao, Wenchi Wang, Xiaochen Gao, Dan Wang, Lidan Zhao* and Wenfang Li*,

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Abstract

The continuous interaction between tumor cells and the local microenvironment plays a decisive role in tumor development. Selecting effective models to simulate the tumor microenvironment to study the physiological processes of tumorigenesis and progression is extremely important and challenging. Currently, three-dimensional (3D) bioprinting technology makes it possible to replicate a physiologically relevant tumor microenvironment and induce genomic and proteomic expression to better mimic tumors in vivo. Meanwhile, it plays a crucial role in the prevention and treatment of human diseases, contributing to drug delivery and drug screening, tissue development and regenerative medicine. This paper provides an overview of the categories of 3D bioprinting technology, and the recent advances in the bioinks required for printing. In addition, we summarize the current tumor models based on 3D bioprinting and provide an assessment of possible future biological applications.

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三维生物打印在癌症建模和生物医学中的应用：从打印类别到生物应用

肿瘤细胞与局部微环境之间的持续相互作用在肿瘤发生发展过程中起着决定性作用。选择有效的肿瘤微环境模拟模型来研究肿瘤发生和发展的生理过程极为重要，也极具挑战性。目前，三维（3D）生物打印技术可以复制与生理相关的肿瘤微环境，并诱导基因组和蛋白质组表达，从而更好地模拟体内肿瘤。同时，它在预防和治疗人类疾病方面发挥着至关重要的作用，有助于药物输送和药物筛选、组织开发和再生医学。本文概述了三维生物打印技术的类别，以及打印所需的生物墨水的最新进展。此外，我们还总结了目前基于三维生物打印技术的肿瘤模型，并对未来可能的生物应用进行了评估。

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