Comparison of the therapeutic effect of Paxlovid and Azvudine in the treatment of COVID-19: A retrospective study

IF 4.7 3区 医学 Q1 INFECTIOUS DISEASES Journal of Infection and Public Health Pub Date : 2024-10-31 DOI:10.1016/j.jiph.2024.102583
Wei Yang , Weiting Zhang , Jing Zhou , Xinyue Ma , Changsong Wang , Mingyan Zhao , Kaijiang Yu
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Abstract

Background

COVID-19 pneumonia has spread across China and globally since late 2019, becoming a pandemic. Its extremely contagious nature as well as high morbidity and mortality rates have attracted widespread attention globally. For the treatment of SARS-CoV-2 pneumonia, two commonly used antiviral drugs in the clinic are nirmatrelvir/ritonavir(Paxlovid) and Azvudine, while the therapeutic efficacy of the two drugs and their impact on patient prognosis remain inconclusive. Therefore, the aim of this study is to investigate the effects of two antiviral drugs, Azvudine and Paxlovid, on the disease development and prognosis of patients with COVID-19.

Methods

This study collected and analyzed in Inner Mongolia hospital treated 267 cases of COVID - 19 patients. According to the use of antiviral medications, the participants in this experiment were split into the Azvudine and Paxlovid groups. The effectiveness of the medications was evaluated using the length of hospitalization, Nucleic acid into negative time for the first time, and laboratory indices such as total protein, lymphocytes, leukocytes, albumin, creatinine, and platelets.

Results

Compared with the Azvudine group, patients in the Paxlovid group had a shorter recovery time, a higher degree of rise in lymphocytes, a faster recovery of the immune system, a lower rise in creatinine, and a lesser renal burden, but patients in the Paxlovid group had a greater decrease in total protein.

Conclusion

In assessing patient conditions for treatment selection, Paxlovid may be preferable for individuals with renal insufficiency or those exhibiting compromised immune responses. Conversely, for patients experiencing malnutrition or cirrhotic hypoproteinemia, Azvudine could be considered to mitigate the reduction in protein levels.
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比较 Paxlovid 和阿兹夫定治疗 COVID-19 的疗效:回顾性研究
背景COVID-19 肺炎自 2019 年底以来在中国乃至全球蔓延,成为一种大流行病。其传染性极强、发病率和死亡率高的特点引起了全球的广泛关注。对于SARS-CoV-2肺炎的治疗,临床上常用的两种抗病毒药物为尼马瑞韦/利托那韦(百服宁)和阿孜夫定,而这两种药物的疗效及其对患者预后的影响仍无定论。因此,本研究旨在探讨阿兹夫定和帕洛维这两种抗病毒药物对COVID-19患者病情发展和预后的影响。方法本研究收集并分析了内蒙古医院收治的267例COVID-19患者。根据抗病毒药物的使用情况,实验参与者被分为阿兹夫定组和帕克洛韦组。通过住院时间、核酸首次转阴时间以及总蛋白、淋巴细胞、白细胞、白蛋白、肌酐和血小板等实验室指标来评估药物疗效。结果与阿兹夫定组相比,帕克洛韦组患者的恢复时间更短、淋巴细胞上升幅度更高、免疫系统恢复更快、肌酐上升幅度更低、肾脏负担更轻,但帕克洛韦组患者的总蛋白下降幅度更大。相反,对于营养不良或肝硬化低蛋白血症患者,可以考虑使用阿兹夫定来缓解蛋白质水平的降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Infection and Public Health
Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES
CiteScore
13.10
自引率
1.50%
发文量
203
审稿时长
96 days
期刊介绍: The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.
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