Causal relationship between cortical structural changes and onset of anxiety disorder: evidence from Mendelian randomization.

IF 2.9 2区 医学 Q2 NEUROSCIENCES Cerebral cortex Pub Date : 2024-11-05 DOI:10.1093/cercor/bhae440
Fei Teng, Mengqi Wang, Zhangyu Lu, Chunyu Zhang, Linglong Xiao, ZhaoMing Chen, Mengshuang Huang, Linglin Xie, Zheyu Chen, Wei Wang
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Abstract

Previous studies have reported a correlation between anxiety disorders and changes in brain structure, yet the specific alterations in brain region volumes remain unclear. This study aimed to infer the causal relationship between anxiety disorders and changes in brain structure volume through Mendelian Randomization analysis. We selected 63 cortical structure volumes from the GWAS database as exposure data and anxiety disorder data from the FinnGen and UK Biobank databases as outcomes. We found a significant correlation between atrophy in the Left precentral volume area (Odds Ratio [OR] = 0.935, 95% Confidence intervals [CI]: 0.891-0.981, P value, P = 0.007) and an increased risk of anxiety disorders. Additionally, changes identified in specific brain regions, such as atrophy in the Right rostral anterior cingulate area (OR = 0.993, 95% CI: 0.987-0.999, P = 0.025) and increased volume in the Left superior parietal area (OR = 1.001, 95% CI: 1.000-1.001, P = 0.028), may correlate with an increased risk of anxiety disorders. Furthermore, both phenotypes demonstrated directional consistency in their respective and overall meta-analyzed OR values pre- and post-merger, enhancing the reliability of the results. This study elucidates the causal relationship between anxiety disorders and specific brain structures, providing new insights for further research into psychiatric disorders.

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皮层结构变化与焦虑症发病之间的因果关系:孟德尔随机化的证据。
以往的研究表明,焦虑症与大脑结构变化之间存在相关性,但大脑区域体积的具体变化仍不清楚。本研究旨在通过孟德尔随机分析法推断焦虑症与大脑结构体积变化之间的因果关系。我们从 GWAS 数据库中选取了 63 个皮层结构体积作为暴露数据,并从 FinnGen 和英国生物库数据库中选取焦虑症数据作为结果。我们发现,左侧前中央区体积萎缩(Odds Ratio [OR] = 0.935,95% 置信区间 [CI]:0.891-0.981)与焦虑症之间存在明显的相关性:0.891-0.981,P 值,P = 0.007)与焦虑症风险增加之间存在显著相关性。此外,在特定脑区发现的变化,如右侧喙状前扣带回区萎缩(OR = 0.993,95% CI:0.987-0.999,P = 0.025)和左侧上顶叶区体积增大(OR = 1.001,95% CI:1.000-1.001,P = 0.028),可能与焦虑症风险增加有关。此外,这两种表型在合并前后各自和总体的荟萃分析 OR 值中都表现出方向一致性,从而提高了结果的可靠性。这项研究阐明了焦虑症与特定大脑结构之间的因果关系,为进一步研究精神疾病提供了新的视角。
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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
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