{"title":"Ocular drug delivery strategies using carbon nanotubes: A perspective","authors":"Lidiya Sonowal, Sanjeev Gautam","doi":"10.1016/j.matlet.2024.137642","DOIUrl":null,"url":null,"abstract":"<div><div>Ocular drug delivery has its own set of challenges due to the eye’s complexity and barriers. Various nanocarriers have been developed to deliver drugs to the eye; however, this work focuses on carbon nanotubes (CNTs) as a nanocarrier. CNTs have unique properties that can address the challenges associated with ocular drug delivery. The novelty of this work is to integrate CNTs with ocular drugs to improve solubility, transport across barriers and sustained release. The structure and properties of CNTs are discussed in the context of ophthalmic applications. Functionalization of CNTs to enhance biocompatibility and optimize drug delivery is also discussed with recent updates. The key applications include improving solubility, penetration through ocular barriers and controlled release. Future directions and emerging trends in nanotechnology for ocular drug delivery are also considered herein.</div></div>","PeriodicalId":384,"journal":{"name":"Materials Letters","volume":"379 ","pages":"Article 137642"},"PeriodicalIF":2.7000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Letters","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167577X24017828","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Ocular drug delivery has its own set of challenges due to the eye’s complexity and barriers. Various nanocarriers have been developed to deliver drugs to the eye; however, this work focuses on carbon nanotubes (CNTs) as a nanocarrier. CNTs have unique properties that can address the challenges associated with ocular drug delivery. The novelty of this work is to integrate CNTs with ocular drugs to improve solubility, transport across barriers and sustained release. The structure and properties of CNTs are discussed in the context of ophthalmic applications. Functionalization of CNTs to enhance biocompatibility and optimize drug delivery is also discussed with recent updates. The key applications include improving solubility, penetration through ocular barriers and controlled release. Future directions and emerging trends in nanotechnology for ocular drug delivery are also considered herein.
期刊介绍：
Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials.
Contributions include, but are not limited to, a variety of topics such as:
• Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors
• Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart
• Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction
• Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots.
• Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing.
• Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic
• Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive
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