Effect of antibiotic growth promoters (AGPs) on feed conversion ratio (FCR) of broiler chickens: A meta-analysis.

IF 3.8 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE Poultry Science Pub Date : 2024-10-30 DOI:10.1016/j.psj.2024.104472

Mohamed El-Fateh, Muhammad Bilal, Xin Zhao

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Abstract

Antibiotics have been used for a long time as growth promoters in the poultry industry for growth and health benefits. However, recent studies reflected little, no, or negative impacts of using antibiotics for growth promotion purposes. This study was designed to examine the overall effect of antibiotic supplementation on the feed conversion ratio (FCR) in broiler chickens as a performance indicator and assess different covariates for explaining heterogeneity in response to the use of antibiotics as growth promoters. In this regard, FCRs obtained from articles that compared diets with and without antibiotics for broiler chickens were extracted from electronic databases (PubMed, Web of Science, and Google Scholar) as per PRISMA guidelines. The database comprised 42 scientific articles containing 74 experiments totaling 19,562 chickens. A basic meta-analysis and subgroup analysis were performed to assess the overall impact of antibiotic growth promoters (AGPs) on FCR of broiler chickens while a meta-regression analysis was used to assess different covariates (breed, antibiotic dose, location, time, presence of anticoccidial in the feed, antibiotic type, and housing type) to explain variations in true effect size of the studies. The basic meta-analysis of these studies revealed an overall improvement in FCR by 2.8 % (p < 0.05) due to addition of AGPs than the control group with the confidence interval range from 1.3 to 4.3 % and the prediction interval ranging between -10 and 16 %. The covariates, including breed, dose and location, provided the optimum model fit and explained 53 % of variations in the FCR across different studies. In summary, an overall marginal improvement has been observed in mean FCR of broiler chickens along with a wide range of variations in response to use of AGPs. The variations in true effects among these studies are subject to several confounding effects, particularly breed, dose and location. Considering the marginal positive effect of antibiotic usage in chicken performance, we recommend against using of AGP.

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抗生素生长促进剂（AGPs）对肉鸡饲料转化率（FCR）的影响：荟萃分析。

长期以来，家禽业一直使用抗生素作为生长促进剂，以促进生长和健康。然而，最近的研究表明，使用抗生素促进生长的影响很小、没有影响或有负面影响。本研究旨在考察补充抗生素对作为性能指标的肉鸡饲料转化率（FCR）的总体影响，并评估不同的协变量，以解释使用抗生素作为生长促进剂的异质性。为此，我们按照 PRISMA 指南从电子数据库（PubMed、Web of Science 和 Google Scholar）中提取了比较肉鸡使用和不使用抗生素日粮的 FCR。数据库包括 42 篇科学文章，包含 74 项实验，共计 19,562 只鸡。我们进行了基本荟萃分析和亚组分析，以评估抗生素生长促进剂（AGPs）对肉鸡FCR的总体影响，同时使用荟萃回归分析评估不同的协变量（品种、抗生素剂量、地点、时间、饲料中是否含有抗球虫药、抗生素类型和饲养类型），以解释研究中真实效应大小的差异。对这些研究进行的基本荟萃分析表明，与对照组相比，添加 AGPs 可使 FCR 整体提高 2.8%（p < 0.05），置信区间为 1.3% 至 4.3%，预测区间为 -10% 至 16%。包括品种、剂量和地点在内的协变量提供了最佳模型拟合效果，并解释了不同研究中 FCR 53% 的变化。总之，肉鸡的平均FCR总体上略有提高，但对AGPs的反应却有很大差异。在这些研究中，真实效果的差异受到多种干扰因素的影响，尤其是品种、剂量和地点。考虑到使用抗生素对鸡的生产性能仅有微弱的积极影响，我们建议不要使用 AGP。

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来源期刊

Poultry Science 农林科学-奶制品与动物科学

CiteScore

7.60

自引率

15.90%

发文量

审稿时长

94 days

期刊介绍： First self-published in 1921, Poultry Science is an internationally renowned monthly journal, known as the authoritative source for a broad range of poultry information and high-caliber research. The journal plays a pivotal role in the dissemination of preeminent poultry-related knowledge across all disciplines. As of January 2020, Poultry Science will become an Open Access journal with no subscription charges, meaning authors who publish here can make their research immediately, permanently, and freely accessible worldwide while retaining copyright to their work. Papers submitted for publication after October 1, 2019 will be published as Open Access papers. An international journal, Poultry Science publishes original papers, research notes, symposium papers, and reviews of basic science as applied to poultry. This authoritative source of poultry information is consistently ranked by ISI Impact Factor as one of the top 10 agriculture, dairy and animal science journals to deliver high-caliber research. Currently it is the highest-ranked (by Impact Factor and Eigenfactor) journal dedicated to publishing poultry research. Subject areas include breeding, genetics, education, production, management, environment, health, behavior, welfare, immunology, molecular biology, metabolism, nutrition, physiology, reproduction, processing, and products.