Influence of sleep on physiological systems in atherosclerosis

Abstract

Sleep is a fundamental requirement of life and is integral to health. Deviation from optimal sleep associates with numerous diseases including those of the cardiovascular system. Studies, spanning animal models to humans, show that insufficient, disrupted or inconsistent sleep contribute to poor cardiovascular health by disrupting body systems. Fundamental experiments have begun to uncover the molecular and cellular links between sleep and heart health while large-scale human studies have associated sleep with cardiovascular outcomes in diverse populations. Here, we review preclinical and clinical findings that demonstrate how sleep influences the autonomic nervous, metabolic and immune systems to affect atherosclerotic cardiovascular disease. Kiss et al. review preclinical and clinical evidence illustrating how sleep impacts the nervous, metabolic and immune systems, ultimately influencing the development and progression of atherosclerotic cardiovascular disease.